TY  - JOUR
AU  - Gambichler, Thilo
AU  - Schuleit, Nadine
AU  - Susok, Laura
AU  - Becker, Jürgen
AU  - Scheel, Christina H
AU  - Torres-Reyes, Christian
AU  - Overheu, Oliver
AU  - Reinacher-Schick, Anke
AU  - Schmidt, Wolfgang
TI  - Prognostic Performance of Inflammatory Biomarkers Based on Complete Blood Counts in COVID-19 Patients.
JO  - Viruses
VL  - 15
IS  - 9
SN  - 1999-4915
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-01957
SP  - 1920
PY  - 2023
AB  - With the end of the pandemic, COVID-19 has entered an endemic phase with expected seasonal spikes. Consequently, the implementation of easily accessible prognostic biomarkers for patients with COVID-19 remains an important area of research. In this monocentric study at a German tertiary care hospital, we determined the prognostic performance of different clinical and blood-based parameters in 412 COVID-19 patients. We evaluated the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and absolute eosinopenia (AEP, 0/µL) of COVID-19 patients (n = 412). The Siddiqui and Mehra staging proposal, the WHO clinical progression scale, and COVID-19-associated death were used as COVID-19 outcome measures. With respect to Siddiqi and Mehra staging, patient age of older than 75 years, high C-reactive protein (CRP), absolute eosinopenia (AEP), cardiovascular comorbidities, and high ferritin were significant independent predictors for severe COVID-19. When outcome was determined according to the WHO clinical progression scale, patient age of older than 75 years, high CRP, high LDH, AEP, high neutrophil-to-lymphocyte ratio (NLR), and the presence of pulmonal comorbidities were significant independent predictors for severe COVID-19. Finally, COVID-19-associated death was predicted independently by patient age of older than 75 years, high LDH, high NLR, and AEP. Eosinopenia (< 40/µL) was observed in 74.5
KW  - C-reactive protein (Other)
KW  - SARS-CoV-2 (Other)
KW  - comorbidities (Other)
KW  - eosinopenia (Other)
KW  - eosinophils (Other)
KW  - ferritin (Other)
KW  - lactate dehydrogenase (Other)
KW  - systemic immune-inflammation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37766326
DO  - DOI:10.3390/v15091920
UR  - https://inrepo02.dkfz.de/record/283178
ER  -