000283198 001__ 283198
000283198 005__ 20240229155050.0
000283198 0247_ $$2doi$$a10.3390/biomedicines11092348
000283198 0247_ $$2pmid$$apmid:37760790
000283198 037__ $$aDKFZ-2023-01963
000283198 041__ $$aEnglish
000283198 082__ $$a570
000283198 1001_ $$0P:(DE-He78)857bbcdb8f5f582e00795df8b957767d$$avon Knebel Doeberitz, Nikolaus$$b0$$eFirst author$$udkfz
000283198 245__ $$aPost-Surgical Depositions of Blood Products Are No Major Confounder for the Diagnostic and Prognostic Performance of CEST MRI in Patients with Glioma.
000283198 260__ $$aBasel$$bMDPI$$c2023
000283198 3367_ $$2DRIVER$$aarticle
000283198 3367_ $$2DataCite$$aOutput Types/Journal article
000283198 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1695986928_24400
000283198 3367_ $$2BibTeX$$aARTICLE
000283198 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000283198 3367_ $$00$$2EndNote$$aJournal Article
000283198 500__ $$a#EA:E010#LA:E010#
000283198 520__ $$aAmide proton transfer (APT) and semi-solid magnetization transfer (ssMT) imaging can predict clinical outcomes in patients with glioma. However, the treatment of brain tumors is accompanied by the deposition of blood products within the tumor area in most cases. For this reason, the objective was to assess whether the diagnostic interpretation of the APT and ssMT is affected by methemoglobin (mHb) and hemosiderin (Hs) depositions at the first follow-up MRI 4 to 6 weeks after the completion of radiotherapy. A total of 34 participants underwent APT and ssMT imaging by applying reconstruction methods described by Zhou et al. (APTwasym), Goerke et al. (MTRRexAPT and MTRRexMT) and Mehrabian et al. (MTconst). Contrast-enhancing tumor (CE), whole tumor (WT), mHb and Hs were segmented on contrast-enhanced T1wCE, T2w-FLAIR, T1w and T2*w images. ROC-analysis, Kaplan-Meier analysis and the log rank test were used to test for the association of mean contrast values with therapy response and overall survival (OS) before (WT and CE) and after correcting tumor volumes for mHb and Hs (CEC and WTC). CEC showed higher associations of the MTRRexMT with therapy response (CE: AUC = 0.677, p = 0.081; CEC: AUC = 0.705, p = 0.044) and of the APTwasym with OS (CE: HR = 2.634, p = 0.040; CEC: HR = 2.240, p = 0.095). In contrast, WTC showed a lower association of the APTwasym with survival (WT: HR = 2.304, p = 0.0849; WTC: HR = 2.990, p = 0.020). Overall, a sophisticated correction for blood products did not substantially influence the clinical performance of APT and ssMT imaging in patients with glioma early after radiotherapy.
000283198 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000283198 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000283198 650_7 $$2Other$$aamide proton transfer
000283198 650_7 $$2Other$$ablood
000283198 650_7 $$2Other$$achemical exchange saturation transfer MRI
000283198 650_7 $$2Other$$acorrection
000283198 650_7 $$2Other$$aglioma
000283198 650_7 $$2Other$$ahemosiderin
000283198 650_7 $$2Other$$amethemoglobin
000283198 650_7 $$2Other$$aoverall survival
000283198 650_7 $$2Other$$aradiotherapy
000283198 650_7 $$2Other$$asemi-solid magnetization transfer
000283198 650_7 $$2Other$$atherapy response
000283198 7001_ $$0P:(DE-He78)a803bc5fee5b7b2093f0fe6074f3d2ea$$aKroh, Florian$$b1$$udkfz
000283198 7001_ $$aKönig, Laila$$b2
000283198 7001_ $$0P:(DE-He78)3c51ec0b06b6c9ccece5c7b5306de106$$aBoyd, Philip S$$b3$$udkfz
000283198 7001_ $$0P:(DE-He78)5530f7eeaa1168b3dc8db60db8853490$$aGraß, Svenja$$b4$$udkfz
000283198 7001_ $$0P:(DE-He78)6205350c30f0f6e6364841823c83165a$$aBauspieß, Cora$$b5$$udkfz
000283198 7001_ $$00000-0003-1203-9351$$aScherer, Moritz$$b6
000283198 7001_ $$aUnterberg, Andreas$$b7
000283198 7001_ $$aBendszus, Martin$$b8
000283198 7001_ $$aWick, Wolfgang$$b9
000283198 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b10$$udkfz
000283198 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b11$$udkfz
000283198 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark$$b12$$udkfz
000283198 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b13$$udkfz
000283198 7001_ $$0P:(DE-HGF)0$$aGoerke, Steffen$$b14
000283198 7001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b15$$udkfz
000283198 7001_ $$0P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aPaech, Daniel$$b16$$eLast author$$udkfz
000283198 773__ $$0PERI:(DE-600)2720867-9$$a10.3390/biomedicines11092348$$gVol. 11, no. 9, p. 2348 -$$n9$$p2348$$tBiomedicines$$v11$$x2227-9059$$y2023
000283198 909CO $$ooai:inrepo02.dkfz.de:283198$$pVDB
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)857bbcdb8f5f582e00795df8b957767d$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a803bc5fee5b7b2093f0fe6074f3d2ea$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3c51ec0b06b6c9ccece5c7b5306de106$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5530f7eeaa1168b3dc8db60db8853490$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6205350c30f0f6e6364841823c83165a$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000283198 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000283198 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000283198 9141_ $$y2023
000283198 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2022-01-07T14:28:55Z
000283198 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-03-30
000283198 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-03-30
000283198 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-03-30
000283198 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-03-30
000283198 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-03-30
000283198 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBIOMEDICINES : 2022$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-07-07T16:28:21Z
000283198 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-07-07T16:28:21Z
000283198 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2023-07-07T16:28:21Z
000283198 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-29
000283198 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-29
000283198 9202_ $$0I:(DE-He78)E010-20160331$$kE010$$lE010 Radiologie$$x0
000283198 9201_ $$0I:(DE-He78)E010-20160331$$kE010$$lE010 Radiologie$$x0
000283198 9201_ $$0I:(DE-He78)E020-20160331$$kE020$$lE020 Med. Physik in der Radiologie$$x1
000283198 9201_ $$0I:(DE-He78)E050-20160331$$kE050$$lE050 KKE Strahlentherapie$$x2
000283198 9200_ $$0I:(DE-He78)E010-20160331$$kE010$$lE010 Radiologie$$x0
000283198 980__ $$ajournal
000283198 980__ $$aVDB
000283198 980__ $$aI:(DE-He78)E010-20160331
000283198 980__ $$aI:(DE-He78)E020-20160331
000283198 980__ $$aI:(DE-He78)E050-20160331
000283198 980__ $$aUNRESTRICTED