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@ARTICLE{vonKnebelDoeberitz:283198,
      author       = {N. von Knebel Doeberitz$^*$ and F. Kroh$^*$ and L. König
                      and P. S. Boyd$^*$ and S. Graß$^*$ and C. Bauspieß$^*$ and
                      M. Scherer and A. Unterberg and M. Bendszus and W. Wick and
                      P. Bachert$^*$ and J. Debus$^*$ and M. Ladd$^*$ and H.-P.
                      Schlemmer$^*$ and S. Goerke$^*$ and A. Korzowski$^*$ and D.
                      Paech$^*$},
      title        = {{P}ost-{S}urgical {D}epositions of {B}lood {P}roducts {A}re
                      {N}o {M}ajor {C}onfounder for the {D}iagnostic and
                      {P}rognostic {P}erformance of {CEST} {MRI} in {P}atients
                      with {G}lioma.},
      journal      = {Biomedicines},
      volume       = {11},
      number       = {9},
      issn         = {2227-9059},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01963},
      pages        = {2348},
      year         = {2023},
      note         = {#EA:E010#LA:E010#},
      abstract     = {Amide proton transfer (APT) and semi-solid magnetization
                      transfer (ssMT) imaging can predict clinical outcomes in
                      patients with glioma. However, the treatment of brain tumors
                      is accompanied by the deposition of blood products within
                      the tumor area in most cases. For this reason, the objective
                      was to assess whether the diagnostic interpretation of the
                      APT and ssMT is affected by methemoglobin (mHb) and
                      hemosiderin (Hs) depositions at the first follow-up MRI 4 to
                      6 weeks after the completion of radiotherapy. A total of 34
                      participants underwent APT and ssMT imaging by applying
                      reconstruction methods described by Zhou et al. (APTwasym),
                      Goerke et al. (MTRRexAPT and MTRRexMT) and Mehrabian et al.
                      (MTconst). Contrast-enhancing tumor (CE), whole tumor (WT),
                      mHb and Hs were segmented on contrast-enhanced T1wCE,
                      T2w-FLAIR, T1w and T2*w images. ROC-analysis, Kaplan-Meier
                      analysis and the log rank test were used to test for the
                      association of mean contrast values with therapy response
                      and overall survival (OS) before (WT and CE) and after
                      correcting tumor volumes for mHb and Hs (CEC and WTC). CEC
                      showed higher associations of the MTRRexMT with therapy
                      response (CE: AUC = 0.677, p = 0.081; CEC: AUC = 0.705, p =
                      0.044) and of the APTwasym with OS (CE: HR = 2.634, p =
                      0.040; CEC: HR = 2.240, p = 0.095). In contrast, WTC showed
                      a lower association of the APTwasym with survival (WT: HR =
                      2.304, p = 0.0849; WTC: HR = 2.990, p = 0.020). Overall, a
                      sophisticated correction for blood products did not
                      substantially influence the clinical performance of APT and
                      ssMT imaging in patients with glioma early after
                      radiotherapy.},
      keywords     = {amide proton transfer (Other) / blood (Other) / chemical
                      exchange saturation transfer MRI (Other) / correction
                      (Other) / glioma (Other) / hemosiderin (Other) /
                      methemoglobin (Other) / overall survival (Other) /
                      radiotherapy (Other) / semi-solid magnetization transfer
                      (Other) / therapy response (Other)},
      cin          = {E010 / E020 / E050},
      ddc          = {570},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331 /
                      I:(DE-He78)E050-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37760790},
      doi          = {10.3390/biomedicines11092348},
      url          = {https://inrepo02.dkfz.de/record/283198},
}