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| 001 | 283203 | ||
| 005 | 20240229155050.0 | ||
| 024 | 7 | _ | |a 10.1002/mrm.29863 |2 doi |
| 024 | 7 | _ | |a pmid:37753844 |2 pmid |
| 024 | 7 | _ | |a 1522-2594 |2 ISSN |
| 024 | 7 | _ | |a 0740-3194 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2023-01968 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Tkotz, Katharina |0 0000-0002-0847-2729 |b 0 |
| 245 | _ | _ | |a Multi-echo-based fat artifact correction for CEST MRI at 7 T. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2024 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1701341444_1991 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:E020# / 2024 Feb;91(2):481-496 |
| 520 | _ | _ | |a CEST MRI is influenced by fat signal, which can reduce the apparent CEST contrast or lead to pseudo-CEST effects. Our goal was to develop a fat artifact correction based on multi-echo fat-water separation that functions stably for 7 T knee MRI data.Our proposed algorithm utilizes the full complex data and a phase demodulation with an off-resonance map estimation based on the Z-spectra prior to fat-water separation to achieve stable fat artifact correction. Our method was validated and compared to multi-echo-based methods originally proposed for 3 T by Bloch-McConnell simulations and phantom measurements. Moreover, the method was applied to in vivo 7 T knee MRI examinations and compared to Gaussian fat saturation and a published single-echo Z-spectrum-based fat artifact correction method.Phase demodulation prior to fat-water separation reduced the occurrence of fat-water swaps. Utilizing the complex signal data led to more stable correction results than working with magnitude data, as was proposed for 3 T. Our approach reduced pseudo-nuclear Overhauser effects compared to the other correction methods. Thus, the mean asymmetry contrast at 3.5 ppm in cartilage over five volunteers increased from -9.2% (uncorrected) and -10.6% (Z-spectrum-based) to -1.5%. Results showed higher spatial stability than with the fat saturation pulse.Our work demonstrates the feasibility of multi-echo-based fat-water separation with an adaptive fat model for fat artifact correction for CEST MRI at 7 T. Our approach provided better fat artifact correction throughout the entire spectrum and image than the fat saturation pulse or Z-spectrum-based correction method for both phantom and knee imaging results. |
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| 650 | _ | 7 | |a 7 T |2 Other |
| 650 | _ | 7 | |a CEST |2 Other |
| 650 | _ | 7 | |a fat artifact |2 Other |
| 650 | _ | 7 | |a fat-water separation |2 Other |
| 650 | _ | 7 | |a knee imaging |2 Other |
| 650 | _ | 7 | |a nuclear Overhauser effect |2 Other |
| 700 | 1 | _ | |a Liebert, Andrzej |0 0000-0002-8450-3021 |b 1 |
| 700 | 1 | _ | |a Gast, Lena V |0 0000-0002-4599-1122 |b 2 |
| 700 | 1 | _ | |a Zeiger, Paula |b 3 |
| 700 | 1 | _ | |a Uder, Michael |b 4 |
| 700 | 1 | _ | |a Zaiss, Moritz |b 5 |
| 700 | 1 | _ | |a Nagel, Armin |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/mrm.29863 |g p. mrm.29863 |0 PERI:(DE-600)1493786-4 |n 2 |p 481-496 |t Magnetic resonance in medicine |v 91 |y 2024 |x 1522-2594 |
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