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@ARTICLE{Blickle:283208,
      author       = {P. Blickle$^*$ and A. Haussmann$^*$ and B. Holzner and A.
                      K. Berger and K. Steindorf$^*$ and M. Schmidt$^*$},
      title        = {{P}roviding the basis for a patient-centred and effective
                      screening for cancer-related fatigue ({MERLIN} study):
                      design of a longitudinal observational study.},
      journal      = {BMJ open},
      volume       = {13},
      number       = {9},
      issn         = {2044-6055},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DKFZ-2023-01973},
      pages        = {e073802},
      year         = {2023},
      note         = {#EA:C110#LA:C110#},
      abstract     = {Cancer-related fatigue (CRF) is a frequent and burdensome
                      sequela of cancer and cancer therapies. It can persist from
                      months to years and has a substantial impact on patients'
                      quality of life and functioning. CRF is often still not
                      adequately diagnosed and insufficiently treated. According
                      to guideline recommendations, patients should be routinely
                      screened for CRF from cancer diagnosis onwards. We will
                      investigate how an effective screening should be designed
                      regarding timing, frequency, screening type and cut-off
                      points.MERLIN is a longitudinal observational study that
                      will include 300 patients with cancer at the beginning of
                      cancer therapy. The main study centre is the National Center
                      for Tumour Diseases Heidelberg, Germany. Patients answer
                      five items to shortly screen for CRF at high frequency
                      during their therapy and at lower frequency during the
                      post-treatment phase for 18 months. Further, CRF is assessed
                      at wider intervals based on the Cella criteria, the Brief
                      Fatigue Inventory impact scale, the quality of life fatigue
                      questionnaire (QLQ-FA12) and the fatigue and cognitive items
                      of the quality of life core questionnaire (QLQ-C30), both of
                      the European Organisation for Research and Treatment of
                      Cancer. Important psychological, socio-demographical or
                      medical factors, which may exacerbate CRF are assessed. All
                      assessments are performed online. Receiver operating curves,
                      areas under the curve, sensitivity, specificity, positive
                      and negative predictive values and likelihood ratios will be
                      calculated to determine optimal short screening
                      modalities.The study was approved by the ethics committee of
                      the Medical Faculty of the Heidelberg University, Germany
                      (approval number: S-336/2022). Written informed consent is
                      obtained from all participants. The study is conducted in
                      full conformance with the principles of the Declaration of
                      Helsinki. Results will be published in peer-reviewed
                      scientific journals, presented at conferences and
                      communicated to clinical stakeholders to foster the
                      implementation of an effective CRF
                      management.ClinicalTrials.gov; registration number:
                      NCT05448573.},
      keywords     = {clinical trial (Other) / fatigue (Other) / oncology (Other)
                      / patient reported outcome measures (Other) /
                      patient-centered care (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37770278},
      doi          = {10.1136/bmjopen-2023-073802},
      url          = {https://inrepo02.dkfz.de/record/283208},
}