TY  - JOUR
AU  - Kersting, David
AU  - Moraitis, Alexandros
AU  - Sraieb, Miriam
AU  - Zarrad, Fadi
AU  - Umutlu, Lale
AU  - Rischpler, Christoph
AU  - Peter Fendler, Wolfgang
AU  - Herrmann, Ken
AU  - Weber, Manuel
AU  - Conti, Maurizio
AU  - Fragoso Costa, Pedro
AU  - Jentzen, Walter
TI  - Quantification performance of silicon photomultiplier-based PET for small 18F-, 68Ga- and 124I-avid lesions in the context of radionuclide therapy planning.
JO  - Physica medica
VL  - 114
SN  - 1120-1797
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2023-01979
SP  - 103149
PY  - 2023
N1  - 2023 Oct:114:103149
AB  - The aim of this study was to investigate conditions for reliable quantification of sub-centimeter lesions with low18F,68Ga, and124I uptake using a silicon photomultiplier-based PET/CT system.A small tumor phantom was investigated under challenging but clinically realistic conditions resembling prostate and thyroid cancer lymph node metastases (6 spheres with 3.7-9.7 mm in diameter, 9 different activity concentrations ranging from about 0.25-25 kBq/mL, and a signal-to-background ratio of 20). Radionuclides with different positron branching ratios and prompt gamma coincidence contributions were investigated. Maximum-, contour-, and oversize-based partial volume effect (PVE) correction approaches were applied. Detection and quantification performance were estimated, considering a ±30 
KW  - Digital PET/CT (Other)
KW  - Dosimetry (Other)
KW  - Radionuclide Therapy Planning (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37778973
DO  - DOI:10.1016/j.ejmp.2023.103149
UR  - https://inrepo02.dkfz.de/record/284385
ER  -