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@ARTICLE{Kersting:284385,
      author       = {D. Kersting$^*$ and A. Moraitis$^*$ and M. Sraieb$^*$ and
                      F. Zarrad$^*$ and L. Umutlu$^*$ and C. Rischpler$^*$ and W.
                      Peter Fendler$^*$ and K. Herrmann$^*$ and M. Weber$^*$ and
                      M. Conti and P. Fragoso Costa$^*$ and W. Jentzen$^*$},
      title        = {{Q}uantification performance of silicon
                      photomultiplier-based {PET} for small 18{F}-, 68{G}a- and
                      124{I}-avid lesions in the context of radionuclide therapy
                      planning.},
      journal      = {Physica medica},
      volume       = {114},
      issn         = {1120-1797},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01979},
      pages        = {103149},
      year         = {2023},
      note         = {2023 Oct:114:103149},
      abstract     = {The aim of this study was to investigate conditions for
                      reliable quantification of sub-centimeter lesions with
                      low18F,68Ga, and124I uptake using a silicon
                      photomultiplier-based PET/CT system.A small tumor phantom
                      was investigated under challenging but clinically realistic
                      conditions resembling prostate and thyroid cancer lymph node
                      metastases (6 spheres with 3.7-9.7 mm in diameter, 9
                      different activity concentrations ranging from about 0.25-25
                      kBq/mL, and a signal-to-background ratio of 20).
                      Radionuclides with different positron branching ratios and
                      prompt gamma coincidence contributions were investigated.
                      Maximum-, contour-, and oversize-based partial volume effect
                      (PVE) correction approaches were applied. Detection and
                      quantification performance were estimated, considering a
                      ±30 $\%$ deviation between imaged-derived and true activity
                      concentrations as acceptable. A standard and a prolonged
                      acquisition time and two image reconstruction algorithms
                      (time-of-flight with/without point spread function
                      modelling) were analyzed. Clinical data were evaluated to
                      assess agreement of PVE-correction approaches indicating
                      lesion quantification validity.The smallest 3.7-mm sphere
                      was not visible. If the lesions were clearly observed,
                      quantification was, except for a few cases, acceptable using
                      contour- or oversized-based PVE-corrections. Quantification
                      accuracy did not substantially differ between 18F, 68Ga, and
                      124I. No systematic differences between the analyzed
                      reconstruction algorithms or shorter and larger acquisition
                      times were observed. In the clinical evaluation of 20
                      lesions, an excellent statistical agreement between
                      oversize- and contour-based PVE-corrections was observed.At
                      the lower end of size (<10 mm) and activity concentration
                      ranges of lymph-node metastases, quantification with
                      reasonable accuracy is possible for 18F, 68Ga, and 124I,
                      possibly allowing pre-therapeutic lesion dosimetry and
                      individualized radionuclide therapy planning.},
      keywords     = {Digital PET/CT (Other) / Dosimetry (Other) / Radionuclide
                      Therapy Planning (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37778973},
      doi          = {10.1016/j.ejmp.2023.103149},
      url          = {https://inrepo02.dkfz.de/record/284385},
}