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@ARTICLE{Bernhardt:284393,
      author       = {D. Bernhardt$^*$ and J. C. Peeken and V. Kehl and K. Eitz
                      and M. Guckenberger and N. Andratschke and M. C. Mayinger
                      and K. Lindel and K. Dieckmann and R. El Shafie and J.
                      Debus$^*$ and O. Riesterer and S. Rogers and O. Blanck and
                      R. Wolff and A. Grosu$^*$ and A. Bilger and C. Henkenberens
                      and K. Schulze and C. Gani and A. C. Müller and K.
                      Radlanski and S. Janssen and K. Ferentinos and S. E. Combs},
      title        = {{P}ost-{O}perative {S}tereotactic {R}adiotherapy for
                      {R}esected {B}rain {M}etastases: {R}esults of the
                      {M}ulticenter {A}nalysis ({AURORA}) of the {G}erman
                      {W}orking {G}roup '{S}tereotactic {R}adiotherapy'.},
      journal      = {International journal of radiation oncology, biology,
                      physics},
      volume       = {117},
      number       = {2S},
      issn         = {0360-3016},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01982},
      pages        = {e87 - e88},
      year         = {2023},
      abstract     = {While the results of prospective studies support the use of
                      postoperative stereotactic radiotherapy (RT) to the
                      resection cavity (RC) as the standard of care after surgery,
                      there are several issues that need to be investigated such
                      as factors for improving local control, risk of
                      leptomeningeal disease and radiation necrosis. Further, the
                      optimal dose and fractionation is still under debate.The
                      working group 'Stereotactic Radiotherapy' of the German
                      Society of Radiation Oncology (DEGRO) analyzed its
                      multi-institutional database with 661 patients who received
                      postoperative stereotactic RT to the RC. Treatment was
                      performed at 13 centers between 2008 and 2021. Patient
                      characteristics, treatment details, and follow-up data
                      including overall survival (OS), local control (LC) were
                      evaluated. Cox Regression and Kaplan-Meier curves with
                      Log-rank Tests were calculated for selected variables.In
                      this retrospective study, overall survival was $61.5\%$ at 1
                      year, $47.6\%$ at 2 years, and $35.5\%$ at 3 years, and
                      local control was $84.6\%$ at 1 year, $74.8\%$ at 2 years,
                      and $72.8\%$ at 3 years. $96\%$ of patients were treated
                      with hypofractionated stereotactic radiotherapy (HSRT), only
                      26 patients received single fraction radiosurgery $(4\%).$
                      Prognostic factors associated with overall survival were
                      Karnofsky Performance Status, RPA and GPA class, controlled
                      primary tumor and absence of extracranial metastases,
                      whereas prognostic factor associated with local control was
                      planning target volume (23 mL or less).HSRT is the most
                      common fractionation form in the treatment of RCs in this
                      multicenter analysis. This approach results in excellent OS
                      and LC outcomes. OS in patients with resected brain
                      metastases is mainly influenced by performance status. In
                      regard to local control, RT of large cavities remain a
                      challenge with significantly worse outcome.},
      cin          = {MU01 / E050 / HD01 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331 / I:(DE-He78)E050-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37786203},
      doi          = {10.1016/j.ijrobp.2023.06.842},
      url          = {https://inrepo02.dkfz.de/record/284393},
}