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@ARTICLE{Group:284413,
author = {M. E. Grams and J. Coresh and K. Matsushita and S. H.
Ballew and Y. Sang and A. Surapaneni and N. Alencar de Pinho
and A. Anderson and L. J. Appel and J. Ärnlöv and F. Azizi
and N. Bansal and S. Bell and H. J. G. Bilo and N. J.
Brunskill and J. J. Carrero and S. Chadban and J. Chalmers
and J. Chen and E. Ciemins and M. Cirillo and N. Ebert and
M. Evans and A. Ferreiro and E. L. Fu and M. Fukagawa and J.
A. Green and O. M. Gutierrez and W. G. Herrington and S.-J.
Hwang and L. A. Inker and K. Iseki and T. Jafar and S. K.
Jassal and V. Jha and A. Kadota and R. Katz and A. Köttgen
and T. Konta and F. Kronenberg and B. J. Lee and J. Lees and
A. Levin and H. C. Looker and R. Major and C. Melzer Cohen
and M. Mieno and M. Miyazaki and O. Moranne and I. Muraki
and D. Naimark and D. Nitsch and W. Oh and M. Pena and T. S.
Purnell and C. Sabanayagam and M. Satoh and S. Sawhney and
E. Schaeffner and B. Schöttker$^*$ and J. I. Shen and M. G.
Shlipak and S. Sinha and B. Stengel and K. Sumida and M.
Tonelli and J. M. Valdivielso and A. D. van Zuilen and F. L.
J. Visseren and A. Y. Wang and C.-P. Wen and D. C. Wheeler
and H. Yatsuya and K. Yamagata and J. W. Yang and A. Young
and H. Zhang and L. Zhang and A. S. Levey and R. T.
Gansevoort},
collaboration = {W. Group and CKD Prognosis Consortium},
othercontributors = {L. J. Appel and M. Grams and M. Woodward and K. Harris and
H. Arima and J. Chalmers and H. Yatsuya and K. Tamakoshi and
Y. Li and J. Coresh and Y. Sang and K. Matsushita and K.
Polkinghorne and S. Chadban and A. Levin and O. Djurdjev and
M. Tang and L. Zhang and F. Wang and J. Wang and M.-H. Zhao
and E. Schaeffner and N. Ebert and N. Mielke and M. Tonelli
and A. Lloyd and F. Sacks and M. G. Shlipak and N. Bansal
and M. Sarnak and K. Yamagishi and I. Muraki and Y. Shimizu
and H. Iso and M. Fukagawa and S. Maruyama and T. Hamano and
N. Fujii and T. Imaizumi and N. Alencar De Pinho and M.
Metzger and B. Stengel and A. Hamroun and Z. Massy and T. H.
Jafar and I. Jehan and J. Hatcher and N. Chaturvedi and N.
Poulter and D. C. Wheeler and M. Landray and A. Anderson and
J. Chen and J. Lash and J. Taliercio and P. W. Yang and K.
Tuttle and R. Alicic and S. Nicholas and J. Shen and B.
Schöttker and H. Stocker and D. Rothenbacher and H. Brenner
and D. Levy and S.-J. Hwang and M. P. Schneider and A.
Köttgen and H. Meiselbach and K.-U. Eckardt and A. R. Chang
and J. A. Green and H. L. Kirchner and G. Singh and S.
Sawhney and C. Black and K. Wilde and A. Marks and S. Bell
and M. Siddiqui and C. Palmer and E. Pearson and M. Miyazaki
and M. Nakayama and T. Yamamoto and G. Yamada and S. Ito and
M. Cirillo and A. Y. Wang and H. H. Wu and H. C. Cheung and
V. Ngai and T. K. Tak and A. X. Garg and E. McArthur and A.
Young and V. Jha and A. K. Yadav and V. Kumar and A. P.
Carson and B. A. Young and C. Diamantidis and Y.-I. Min and
T. S. Purnell and S. Ishikawa and M. Mieno and K. Yamagata
and K. Iseki and K. Asahi and T. Konta and B. J. Lee and N.
J. Brunskill and L. Gray and R. Major and J. Medcalf and G.
Chodick and C. Melzer Cohen and J. F. Wetzels and P. J.
Blankestijn and A. D. van Zuilen and L. A. Inker and A. S.
Levey and J. Ix and I. de Boer and R. Katz and F. Kronenberg
and B. Kollerits and E. Ritz and D. Nitsch and G. N.
Nadkarni and L. Chan and E. P. Bottinger and W. Oh and Z.
Liu and H. Zhang and L. Zhang and J. M. Valdivielso and M.
Bermudez-Lopez and M. Bozic and M. Caus and J. M.
Diaz-Tocados and B. Stengel and K. Miura and H. Ueshima and
A. Okayama and A. Kadota and T. Okamura and L. Sola and A.
Ferreiro and J. Santiago and P. Rios and L. Gadola and R.
Silvariño and T. Ohkubo and M. Satoh and H. Metoki and M.
Kikuya and E. Ciemins and J. Mohl and R. G. Nelson and R. L.
Hanson and H. C. Looker and R. T. Gansevoort and L. M.
Kieneker and S. J. Bakker and O. Moranne and C. Couchoud and
D. Shepherd and S. K. Jassal and J. Bergstrom and C. P.
Kovesdy and K. Sumida and P. Shrestha and O. Gutierrez and
K. Cheung and P. Muntner and T. Ilori and M. Pena and H. J.
Heerspink and E. L. Fu and C.-G. Elinder and P. Barany and
J. J. Carrero and M. Evans and C. Sabanayagam and C.-Y.
Cheng and T. Y. Wong and C. C. C. Yuen and W. Herrington and
N. Staplin and M. J. Landray and C. Baigent and P. Kalra and
R. Chinnadurai and D. Green and S. Sinha and J. Ritchie and
F. L. Visseren and P. Burger and M. Emmelot and B. van
Welzen and O. John and B. Gummidi and A. Ghosh and D.
Naimark and N. Tangri and C.-P. Wen and M.-K. Tsai and Y.
Ueno and M. Watanabe and K. Ichikawa and M. Mirbolouk and F.
Azizi and F. Hadaegh and F. Hosseinpanah and W. Shi and D.
Arking and J. Ärnlöv and A. Larsson and V. Giedraitis and
P. Mark and J. Traynor and M. Sullivan and J. Lees and J. W.
Yang and J. I. Shin and J. Y. Lee and J. S. Kim and H. J.
Bilo and P. van Dijk and M. Edens and J. Dille and S. H.
Ballew and J.-J. Carrero and M. E. Grams and J. Chen and A.
Surapaneni},
title = {{E}stimated {G}lomerular {F}iltration {R}ate,
{A}lbuminuria, and {A}dverse {O}utcomes: {A}n
{I}ndividual-{P}articipant {D}ata {M}eta-{A}nalysis.},
journal = {The journal of the American Medical Association},
volume = {330},
number = {13},
issn = {0254-9077},
address = {Chicago, Ill.},
publisher = {American Medical Association},
reportid = {DKFZ-2023-02002},
pages = {1266},
year = {2023},
abstract = {Chronic kidney disease (low estimated glomerular filtration
rate [eGFR] or albuminuria) affects approximately $14\%$ of
adults in the US.To evaluate associations of lower eGFR
based on creatinine alone, lower eGFR based on creatinine
combined with cystatin C, and more severe albuminuria with
adverse kidney outcomes, cardiovascular outcomes, and other
health outcomes.Individual-participant data meta-analysis of
27 503 140 individuals from 114 global cohorts (eGFR based
on creatinine alone) and 720 736 individuals from 20 cohorts
(eGFR based on creatinine and cystatin C) and 9 067 753
individuals from 114 cohorts (albuminuria) from 1980 to
2021.The Chronic Kidney Disease Epidemiology Collaboration
2021 equations for eGFR based on creatinine alone and eGFR
based on creatinine and cystatin C; and albuminuria
estimated as urine albumin to creatinine ratio (UACR).The
risk of kidney failure requiring replacement therapy,
all-cause mortality, cardiovascular mortality, acute kidney
injury, any hospitalization, coronary heart disease, stroke,
heart failure, atrial fibrillation, and peripheral artery
disease. The analyses were performed within each cohort and
summarized with random-effects meta-analyses.Within the
population using eGFR based on creatinine alone (mean age,
54 years [SD, 17 years]; $51\%$ were women; mean follow-up
time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90
mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR
was 11 mg/g (IQR, 8-16 mg/g). Within the population using
eGFR based on creatinine and cystatin C (mean age, 59 years
[SD, 12 years]; $53\%$ were women; mean follow-up time, 10.8
years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2
(SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR,
6-18 mg/g). Lower eGFR (whether based on creatinine alone or
based on creatinine and cystatin C) and higher UACR were
each significantly associated with higher risk for each of
the 10 adverse outcomes, including those in the mildest
categories of chronic kidney disease. For example, among
people with a UACR less than 10 mg/g, an eGFR of 45 to 59
mL/min/1.73 m2 based on creatinine alone was associated with
significantly higher hospitalization rates compared with an
eGFR of 90 to 104 mL/min/1.73 m2 (adjusted hazard ratio, 1.3
$[95\%$ CI, 1.2-1.3]; 161 vs 79 events per 1000
person-years; excess absolute risk, 22 events per 1000
person-years $[95\%$ CI, 19-25 events per 1000
person-years]).In this retrospective analysis of 114
cohorts, lower eGFR based on creatinine alone, lower eGFR
based on creatinine and cystatin C, and more severe UACR
were each associated with increased rates of 10 adverse
outcomes, including adverse kidney outcomes, cardiovascular
diseases, and hospitalizations.},
cin = {C070},
ddc = {610},
cid = {I:(DE-He78)C070-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:37787795},
doi = {10.1001/jama.2023.17002},
url = {https://inrepo02.dkfz.de/record/284413},
}
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