%0 Journal Article
%A Wichert, Katharina
%A Hoppe, Reiner
%A Ickstadt, Katja
%A Behrens, Thomas
%A Winter, Stefan
%A Herold, Robert
%A Terschüren, Claudia
%A Lo, Wing-Yee
%A Guénel, Pascal
%A Truong, Thérèse
%A Bolla, Manjeet K
%A Wang, Qin
%A Dennis, Joe
%A Michailidou, Kyriaki
%A Lush, Michael
%A Andrulis, Irene L
%A Brenner, Hermann
%A Chang-Claude, Jenny
%A Cox, Angela
%A Cross, Simon S
%A Czene, Kamila
%A Eriksson, Mikael
%A Figueroa, Jonine D
%A García-Closas, Montserrat
%A Goldberg, Mark S
%A Hamann, Ute
%A He, Wei
%A Holleczek, Bernd
%A Hopper, John L
%A Jakubowska, Anna
%A Ko, Yon-Dschun
%A Lubiński, Jan
%A Mulligan, Anna Marie
%A Obi, Nadia
%A Rhenius, Valerie
%A Shah, Mitul
%A Shu, Xiao-Ou
%A Simard, Jacques
%A Southey, Melissa C
%A Zheng, Wei
%A Dunning, Alison M
%A Pharoah, Paul D P
%A Hall, Per
%A Easton, Douglas F
%A Brüning, Thomas
%A Brauch, Hiltrud
%A Harth, Volker
%A Rabstein, Sylvia
%T Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer.
%J European journal of epidemiology
%V 38
%N 10
%@ 0393-2990
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V.
%M DKFZ-2023-02004
%P 1053-1068
%D 2023
%Z 2023 Oct;38(10):1053-1068
%X Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls). Genotype data of 97 candidate single nucleotide polymorphisms (SNPs) at 18 defined gene regions were investigated for breast-cancer risk effects. We calculated adjusted odds ratios (ORs) and 95
%K Circadian rhythm (Other)
%K MAPK8 (Other)
%K Serotonin biosynthesis (Other)
%K Shift work (Other)
%K TPH2 (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37789226
%R 10.1007/s10654-023-01048-7
%U https://inrepo02.dkfz.de/record/284415