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000284415 041__ $$aEnglish
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000284415 1001_ $$00000-0001-7708-7843$$aWichert, Katharina$$b0
000284415 245__ $$aPolymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer.
000284415 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2023
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000284415 500__ $$a2023 Oct;38(10):1053-1068
000284415 520__ $$aLight-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls). Genotype data of 97 candidate single nucleotide polymorphisms (SNPs) at 18 defined gene regions were investigated for breast-cancer risk effects. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CI) by logistic regression for the main-effect analysis as well as stratified analyses by estrogen- and progesterone-receptor (ER, PR) status. SNP-SNP interactions were analyzed via a two-step procedure based on logic regression. The Bayesian false-discovery probability (BFDP) was used for all analyses to account for multiple testing. Noteworthy associations (BFDP < 0.8) included 10 linked SNPs in tryptophan hydroxylase 2 (TPH2) (e.g. rs1386492: OR = 1.07, 95% CI 1.02-1.12), and a SNP in the mitogen-activated protein kinase 8 (MAPK8) (rs10857561: OR = 1.11, 95% CI 1.04-1.18). The SNP-SNP interaction analysis revealed noteworthy interaction terms with TPH2- and MAPK-related SNPs (e.g. rs1386483R ∧ rs1473473D ∧ rs3729931D: OR = 1.20, 95% CI 1.09-1.32). In line with the light-at-night hypothesis that links shift work with elevated breast-cancer risks our results point to SNPs in TPH2 and MAPK-genes that may impact the intricate network of circadian regulation.
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000284415 650_7 $$2Other$$aCircadian rhythm
000284415 650_7 $$2Other$$aMAPK8
000284415 650_7 $$2Other$$aSerotonin biosynthesis
000284415 650_7 $$2Other$$aShift work
000284415 650_7 $$2Other$$aTPH2
000284415 7001_ $$aHoppe, Reiner$$b1
000284415 7001_ $$aIckstadt, Katja$$b2
000284415 7001_ $$aBehrens, Thomas$$b3
000284415 7001_ $$aWinter, Stefan$$b4
000284415 7001_ $$aHerold, Robert$$b5
000284415 7001_ $$aTerschüren, Claudia$$b6
000284415 7001_ $$aLo, Wing-Yee$$b7
000284415 7001_ $$aGuénel, Pascal$$b8
000284415 7001_ $$aTruong, Thérèse$$b9
000284415 7001_ $$aBolla, Manjeet K$$b10
000284415 7001_ $$aWang, Qin$$b11
000284415 7001_ $$aDennis, Joe$$b12
000284415 7001_ $$aMichailidou, Kyriaki$$b13
000284415 7001_ $$aLush, Michael$$b14
000284415 7001_ $$aAndrulis, Irene L$$b15
000284415 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b16$$udkfz
000284415 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b17$$udkfz
000284415 7001_ $$aCox, Angela$$b18
000284415 7001_ $$aCross, Simon S$$b19
000284415 7001_ $$aCzene, Kamila$$b20
000284415 7001_ $$aEriksson, Mikael$$b21
000284415 7001_ $$aFigueroa, Jonine D$$b22
000284415 7001_ $$aGarcía-Closas, Montserrat$$b23
000284415 7001_ $$aGoldberg, Mark S$$b24
000284415 7001_ $$0P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aHamann, Ute$$b25
000284415 7001_ $$aHe, Wei$$b26
000284415 7001_ $$aHolleczek, Bernd$$b27
000284415 7001_ $$aHopper, John L$$b28
000284415 7001_ $$aJakubowska, Anna$$b29
000284415 7001_ $$aKo, Yon-Dschun$$b30
000284415 7001_ $$aLubiński, Jan$$b31
000284415 7001_ $$aMulligan, Anna Marie$$b32
000284415 7001_ $$aObi, Nadia$$b33
000284415 7001_ $$aRhenius, Valerie$$b34
000284415 7001_ $$aShah, Mitul$$b35
000284415 7001_ $$aShu, Xiao-Ou$$b36
000284415 7001_ $$aSimard, Jacques$$b37
000284415 7001_ $$aSouthey, Melissa C$$b38
000284415 7001_ $$aZheng, Wei$$b39
000284415 7001_ $$aDunning, Alison M$$b40
000284415 7001_ $$aPharoah, Paul D P$$b41
000284415 7001_ $$aHall, Per$$b42
000284415 7001_ $$aEaston, Douglas F$$b43
000284415 7001_ $$aBrüning, Thomas$$b44
000284415 7001_ $$0P:(DE-HGF)0$$aBrauch, Hiltrud$$b45
000284415 7001_ $$aHarth, Volker$$b46
000284415 7001_ $$aRabstein, Sylvia$$b47
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