TY  - JOUR
AU  - Wichert, Katharina
AU  - Hoppe, Reiner
AU  - Ickstadt, Katja
AU  - Behrens, Thomas
AU  - Winter, Stefan
AU  - Herold, Robert
AU  - Terschüren, Claudia
AU  - Lo, Wing-Yee
AU  - Guénel, Pascal
AU  - Truong, Thérèse
AU  - Bolla, Manjeet K
AU  - Wang, Qin
AU  - Dennis, Joe
AU  - Michailidou, Kyriaki
AU  - Lush, Michael
AU  - Andrulis, Irene L
AU  - Brenner, Hermann
AU  - Chang-Claude, Jenny
AU  - Cox, Angela
AU  - Cross, Simon S
AU  - Czene, Kamila
AU  - Eriksson, Mikael
AU  - Figueroa, Jonine D
AU  - García-Closas, Montserrat
AU  - Goldberg, Mark S
AU  - Hamann, Ute
AU  - He, Wei
AU  - Holleczek, Bernd
AU  - Hopper, John L
AU  - Jakubowska, Anna
AU  - Ko, Yon-Dschun
AU  - Lubiński, Jan
AU  - Mulligan, Anna Marie
AU  - Obi, Nadia
AU  - Rhenius, Valerie
AU  - Shah, Mitul
AU  - Shu, Xiao-Ou
AU  - Simard, Jacques
AU  - Southey, Melissa C
AU  - Zheng, Wei
AU  - Dunning, Alison M
AU  - Pharoah, Paul D P
AU  - Hall, Per
AU  - Easton, Douglas F
AU  - Brüning, Thomas
AU  - Brauch, Hiltrud
AU  - Harth, Volker
AU  - Rabstein, Sylvia
TI  - Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer.
JO  - European journal of epidemiology
VL  - 38
IS  - 10
SN  - 0393-2990
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2023-02004
SP  - 1053-1068
PY  - 2023
N1  - 2023 Oct;38(10):1053-1068
AB  - Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls). Genotype data of 97 candidate single nucleotide polymorphisms (SNPs) at 18 defined gene regions were investigated for breast-cancer risk effects. We calculated adjusted odds ratios (ORs) and 95
KW  - Circadian rhythm (Other)
KW  - MAPK8 (Other)
KW  - Serotonin biosynthesis (Other)
KW  - Shift work (Other)
KW  - TPH2 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37789226
DO  - DOI:10.1007/s10654-023-01048-7
UR  - https://inrepo02.dkfz.de/record/284415
ER  -