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| Home > Publications database > Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. > print |
| 001 | 284415 | ||
| 005 | 20240918113202.0 | ||
| 024 | 7 | _ | |a 10.1007/s10654-023-01048-7 |2 doi |
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| 037 | _ | _ | |a DKFZ-2023-02004 |
| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Wichert, Katharina |0 0000-0001-7708-7843 |b 0 |
| 245 | _ | _ | |a Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2023 |b Springer Science + Business Media B.V. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1726651889_8429 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2023 Oct;38(10):1053-1068 |
| 520 | _ | _ | |a Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls). Genotype data of 97 candidate single nucleotide polymorphisms (SNPs) at 18 defined gene regions were investigated for breast-cancer risk effects. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CI) by logistic regression for the main-effect analysis as well as stratified analyses by estrogen- and progesterone-receptor (ER, PR) status. SNP-SNP interactions were analyzed via a two-step procedure based on logic regression. The Bayesian false-discovery probability (BFDP) was used for all analyses to account for multiple testing. Noteworthy associations (BFDP < 0.8) included 10 linked SNPs in tryptophan hydroxylase 2 (TPH2) (e.g. rs1386492: OR = 1.07, 95% CI 1.02-1.12), and a SNP in the mitogen-activated protein kinase 8 (MAPK8) (rs10857561: OR = 1.11, 95% CI 1.04-1.18). The SNP-SNP interaction analysis revealed noteworthy interaction terms with TPH2- and MAPK-related SNPs (e.g. rs1386483R ∧ rs1473473D ∧ rs3729931D: OR = 1.20, 95% CI 1.09-1.32). In line with the light-at-night hypothesis that links shift work with elevated breast-cancer risks our results point to SNPs in TPH2 and MAPK-genes that may impact the intricate network of circadian regulation. |
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| 650 | _ | 7 | |a Circadian rhythm |2 Other |
| 650 | _ | 7 | |a MAPK8 |2 Other |
| 650 | _ | 7 | |a Serotonin biosynthesis |2 Other |
| 650 | _ | 7 | |a Shift work |2 Other |
| 650 | _ | 7 | |a TPH2 |2 Other |
| 700 | 1 | _ | |a Hoppe, Reiner |b 1 |
| 700 | 1 | _ | |a Ickstadt, Katja |b 2 |
| 700 | 1 | _ | |a Behrens, Thomas |b 3 |
| 700 | 1 | _ | |a Winter, Stefan |b 4 |
| 700 | 1 | _ | |a Herold, Robert |b 5 |
| 700 | 1 | _ | |a Terschüren, Claudia |b 6 |
| 700 | 1 | _ | |a Lo, Wing-Yee |b 7 |
| 700 | 1 | _ | |a Guénel, Pascal |b 8 |
| 700 | 1 | _ | |a Truong, Thérèse |b 9 |
| 700 | 1 | _ | |a Bolla, Manjeet K |b 10 |
| 700 | 1 | _ | |a Wang, Qin |b 11 |
| 700 | 1 | _ | |a Dennis, Joe |b 12 |
| 700 | 1 | _ | |a Michailidou, Kyriaki |b 13 |
| 700 | 1 | _ | |a Lush, Michael |b 14 |
| 700 | 1 | _ | |a Andrulis, Irene L |b 15 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 16 |u dkfz |
| 700 | 1 | _ | |a Chang-Claude, Jenny |0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253 |b 17 |u dkfz |
| 700 | 1 | _ | |a Cox, Angela |b 18 |
| 700 | 1 | _ | |a Cross, Simon S |b 19 |
| 700 | 1 | _ | |a Czene, Kamila |b 20 |
| 700 | 1 | _ | |a Eriksson, Mikael |b 21 |
| 700 | 1 | _ | |a Figueroa, Jonine D |b 22 |
| 700 | 1 | _ | |a García-Closas, Montserrat |b 23 |
| 700 | 1 | _ | |a Goldberg, Mark S |b 24 |
| 700 | 1 | _ | |a Hamann, Ute |0 P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b |b 25 |
| 700 | 1 | _ | |a He, Wei |b 26 |
| 700 | 1 | _ | |a Holleczek, Bernd |b 27 |
| 700 | 1 | _ | |a Hopper, John L |b 28 |
| 700 | 1 | _ | |a Jakubowska, Anna |b 29 |
| 700 | 1 | _ | |a Ko, Yon-Dschun |b 30 |
| 700 | 1 | _ | |a Lubiński, Jan |b 31 |
| 700 | 1 | _ | |a Mulligan, Anna Marie |b 32 |
| 700 | 1 | _ | |a Obi, Nadia |b 33 |
| 700 | 1 | _ | |a Rhenius, Valerie |b 34 |
| 700 | 1 | _ | |a Shah, Mitul |b 35 |
| 700 | 1 | _ | |a Shu, Xiao-Ou |b 36 |
| 700 | 1 | _ | |a Simard, Jacques |b 37 |
| 700 | 1 | _ | |a Southey, Melissa C |b 38 |
| 700 | 1 | _ | |a Zheng, Wei |b 39 |
| 700 | 1 | _ | |a Dunning, Alison M |b 40 |
| 700 | 1 | _ | |a Pharoah, Paul D P |b 41 |
| 700 | 1 | _ | |a Hall, Per |b 42 |
| 700 | 1 | _ | |a Easton, Douglas F |b 43 |
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| 700 | 1 | _ | |a Harth, Volker |b 46 |
| 700 | 1 | _ | |a Rabstein, Sylvia |b 47 |
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