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@ARTICLE{Brenner:284424,
      author       = {H. Brenner$^*$ and T. Heisser$^*$ and R. Cardoso$^*$ and M.
                      Hoffmeister$^*$},
      title        = {{R}eduction in colorectal cancer incidence by screening
                      endoscopy.},
      journal      = {Nature reviews / Gastroenterology $\&$ hepatology},
      volume       = {21},
      number       = {2},
      issn         = {1759-5045},
      address      = {Basingstoke},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2023-02013},
      pages        = {125-133},
      year         = {2024},
      note         = {#EA:C070#EA:C120#LA:C070# / 2024 Feb;21(2):125-133 /
                      Perspective},
      abstract     = {Colorectal cancer (CRC) incidence rates decreased by up to
                      $50\%$ in older age groups in the USA in the era of the
                      widespread uptake of screening colonoscopy, despite adverse
                      trends in CRC risk factors and increasing CRC incidence at
                      younger ages. However, reported first results from a
                      randomized trial, the NordICC study, suggested rather modest
                      effects of screening colonoscopy. As outlined in this
                      Perspective, the apparent discrepancy between real-world and
                      trial evidence could be explained by strong attenuation of
                      effect estimates from screening endoscopy trials by several
                      factors, including limited screening adherence, widespread
                      uptake of colonoscopy outside the screening offers and the
                      inclusion of prevalent, non-preventable CRC cases in
                      reported numbers of incident cases. Alternative
                      interpretations of screening endoscopy trial results
                      accounting for prevalence bias are in line with trends in
                      CRC incidence reduction in countries offering CRC screening,
                      and should encourage more widespread implementation and
                      uptake of effective CRC screening.},
      subtyp        = {Review Article},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37794234},
      doi          = {10.1038/s41575-023-00847-3},
      url          = {https://inrepo02.dkfz.de/record/284424},
}