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@ARTICLE{Pereira:284603,
      author       = {R. S. Pereira and R. Kumar and A. Cais and L. Paulini and
                      A. Kahler and J. Bravo and V. R. Minciacchi and T. Krack and
                      E. Kowarz and C. Zanetti and P. S. Godavarthy and F. Hoeller
                      and P. Llavona and T. Stark and G. Tascher and D. Nowak and
                      E. Meduri and B. J. P. Huntly and C. Münch and F. Pampaloni
                      and R. Marschalek and D. S. Krause$^*$},
      title        = {{D}istinct and targetable role of calcium-sensing receptor
                      in leukaemia.},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2023-02023},
      pages        = {6242},
      year         = {2023},
      abstract     = {Haematopoietic stem cells (HSC) reside in the bone marrow
                      microenvironment (BMM), where they respond to extracellular
                      calcium [eCa2+] via the G-protein coupled calcium-sensing
                      receptor (CaSR). Here we show that a calcium gradient exists
                      in this BMM, and that [eCa2+] and response to [eCa2+] differ
                      between leukaemias. CaSR influences the location of MLL-AF9+
                      acute myeloid leukaemia (AML) cells within this niche and
                      differentially impacts MLL-AF9+ AML versus BCR-ABL1+
                      leukaemias. Deficiency of CaSR reduces AML leukaemic stem
                      cells (LSC) 6.5-fold. CaSR interacts with filamin A, a
                      crosslinker of actin filaments, affects stemness-associated
                      factors and modulates pERK, β-catenin and c-MYC signaling
                      and intracellular levels of [Ca2+] in MLL-AF9+ AML cells.
                      Combination treatment of cytarabine plus CaSR-inhibition in
                      various models may be superior to cytarabine alone. Our
                      studies suggest CaSR to be a differential and targetable
                      factor in leukaemia progression influencing self-renewal of
                      AML LSC via [eCa2+] cues from the BMM.},
      cin          = {FM01},
      ddc          = {500},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37802982},
      pmc          = {pmc:PMC10558580},
      doi          = {10.1038/s41467-023-41770-0},
      url          = {https://inrepo02.dkfz.de/record/284603},
}