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| Home > Publications database > Digital Rectal Examination Is Not a Useful Screening Test for Prostate Cancer. > print |
| 001 | 284605 | ||
| 005 | 20240229155053.0 | ||
| 024 | 7 | _ | |a 10.1016/j.euo.2023.09.008 |2 doi |
| 024 | 7 | _ | |a pmid:37806841 |2 pmid |
| 024 | 7 | _ | |a altmetric:155203594 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2023-02025 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Krilaviciute, Agne |0 P:(DE-He78)78a9df7108a5b079145be1cb1ab6a315 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Digital Rectal Examination Is Not a Useful Screening Test for Prostate Cancer. |
| 260 | _ | _ | |a Amsterdam |c 2023 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1702549363_27018 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:C130#LA:C130#LA:C020# / 2023 Dec;6(6):566-573 |
| 520 | _ | _ | |a Annual digital rectal examination (DRE) is recommended as a stand-alone screening test for prostate cancer (PCa) in Germany for 45+ yr olds. DRE diagnostic performance in men as young as 45 yr old has not been proved by a screening trial.To determine DRE diagnostic performance in a screening trial.This analysis was conducted within the multicentric, randomized PROBASE trial, which enrolled >46 000 men at age 45 to test risk-adapted prostate-specific antigen (PSA) screening for PCa.(1) DRE was analyzed as a one-time, stand-alone screening offer at age 45 in 6537 men in one arm of the trial and (2) PCa detection by DRE was evaluated at the time of PSA-screen-driven biopsies (N = 578).(1) True-/false-positive detection rates of DRE as compared with PSA screening and (2) DRE outcome at the time of a prostate biopsy were evaluated.(1) A prospective analysis of 57 men with suspicious DRE at age 45 revealed three PCa. Detection rate by DRE was 0.05% (three of 6537) as compared with a four-fold higher rate by PSA screening (48 of 23 301, 0.21%). The true-positive detection rate by DRE relative to screening by PSA was 0.22 (95% confidence interval [CI] = [0.07-0.72]) and the false-positive detection rate by DRE was 2.2 (95% CI = [1.50-3.17]). (2) Among PSA-screen-detected PCa cases, 86% had unsuspicious DRE (sensitivity relative to PSA was 14%), with the majority of these tumors (86%) located in the potentially accessible zones of the prostate as seen by magnetic resonance imaging.The performance of stand-alone DRE to screen for PCa is poor. DRE should not be recommended as a PCa screening test in young men. Furthermore, DRE does not improve the detection of PSA-screen-detected PCa.Our report demonstrated the poor diagnostic performance of digital rectal examination in the screening for prostate cancer in young men. |
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| 650 | _ | 7 | |a Digital rectal examination |2 Other |
| 650 | _ | 7 | |a Prostate cancer |2 Other |
| 650 | _ | 7 | |a Screening |2 Other |
| 700 | 1 | _ | |a Becker, Nikolaus |0 P:(DE-He78)1573258b58c33f1922ca9719d0c8c4ab |b 1 |e First author |u dkfz |
| 700 | 1 | _ | |a Lakes, Jale |b 2 |
| 700 | 1 | _ | |a Radtke, Jan Philipp |b 3 |
| 700 | 1 | _ | |a Kuczyk, Markus |b 4 |
| 700 | 1 | _ | |a Peters, Inga |b 5 |
| 700 | 1 | _ | |a Harke, Nina N |b 6 |
| 700 | 1 | _ | |a Debus, Jürgen |0 P:(DE-He78)8714da4e45acfa36ce87c291443a9218 |b 7 |u dkfz |
| 700 | 1 | _ | |a Koerber, Stefan A |b 8 |
| 700 | 1 | _ | |a Herkommer, Kathleen |b 9 |
| 700 | 1 | _ | |a Gschwend, Jürgen E |b 10 |
| 700 | 1 | _ | |a Meissner, Valentin H |b 11 |
| 700 | 1 | _ | |a Benner, Axel |0 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |b 12 |u dkfz |
| 700 | 1 | _ | |a Seibold, Petra |0 P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215 |b 13 |u dkfz |
| 700 | 1 | _ | |a Kristiansen, Glen |b 14 |
| 700 | 1 | _ | |a Hadaschik, Boris |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Arsov, Christian |b 16 |
| 700 | 1 | _ | |a Schimmöller, Lars |b 17 |
| 700 | 1 | _ | |a Giesel, Frederik Lars |b 18 |
| 700 | 1 | _ | |a Antoch, Gerald |b 19 |
| 700 | 1 | _ | |a Makowski, Marcus |b 20 |
| 700 | 1 | _ | |a Wacker, Frank |b 21 |
| 700 | 1 | _ | |a Schlemmer, Heinz-Peter |0 P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec |b 22 |u dkfz |
| 700 | 1 | _ | |a Kaaks, Rudolf |0 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a |b 23 |e Last author |u dkfz |
| 700 | 1 | _ | |a Albers, Peter |0 P:(DE-He78)f84639cbc39bc20ecda8d00e6de97578 |b 24 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.euo.2023.09.008 |g p. S2588931123002031 |0 PERI:(DE-600)2945338-0 |n 6 |p 566-573 |t European urology oncology |v 6 |y 2023 |x 2588-9311 |
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