%0 Journal Article
%A Klotz, Daniel Martin
%A Link, Theresa
%A Wimberger, Pauline
%A Kuhlmann, Jan Dominik
%T A predictive and prognostic model for surgical outcome and prognosis in ovarian cancer computed by clinico-pathological and serological parameters (CA125, HE4, mesothelin).
%J Clinical chemistry and laboratory medicine
%V 62
%N 3
%@ 1434-6621
%C Berlin [u.a.]
%I De Gruyter
%M DKFZ-2023-02039
%P 530-539
%D 2023
%Z 2023 Oct 11;62(3):530-539
%X Numerous prognostic models have been proposed for ovarian cancer, extending from single serological factors to complex gene-expression signatures. Nonetheless, these models have not been routinely translated into clinical practice. We constructed a robust and readily calculable model for predicting surgical outcome and prognosis of ovarian cancer patients by exploiting commonly available clinico-pathological factors and three selected serum parameters.Serum CA125, human epididymis protein 4 (HE4) and mesothelin (MSL) were quantified by Lumipulse® G chemiluminescent enzyme immunoassay (Fujirebio) in a total of 342 serum samples from 190 ovarian cancer patients, including 152 paired pre- and post-operative samples.Detection of pre-operative HE4 and CA125 was the optimal marker combination for blood-based prediction of surgical outcome (AUC=0.86). We constructed a prognostic model, computed by serum levels of pre-operative CA125, post-operative HE4, post-operative MSL and surgical outcome. Prognostic performance of our model was superior to any of these parameters alone and was independent from BRCA1/2 mutational status. We subsequently transformed our model into a prognostic risk index, stratifying patients as 'lower risk' or 'higher risk'. In 'higher risk' patients, relapse or death was predicted with an AUC of 0.89 and they had a significantly shorter progression free survival (HR: 9.74; 95 
%K CA125 (Other)
%K HE4 (Other)
%K mesothelin (Other)
%K ovarian cancer (Other)
%K prognostic model (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37816681
%R 10.1515/cclm-2023-0314
%U https://inrepo02.dkfz.de/record/284632