% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Magalhes:284644,
      author       = {V. G. Magalhães$^*$ and S. Lukassen and M. Drechsler$^*$
                      and J. Loske and S. Burkart$^*$ and S. Wüst$^*$ and E.-M.
                      Jacobsen and J. Röhmel and M. A. Mall and K.-M. Debatin and
                      R. Eils and S. Autenrieth$^*$ and A. Janda and I. Lehmann
                      and M. Binder$^*$},
      title        = {{I}mmune-epithelial cell cross-talk enhances antiviral
                      responsiveness to {SARS}-{C}o{V}-2 in children.},
      journal      = {EMBO reports},
      volume       = {24},
      number       = {12},
      issn         = {1469-221X},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-02047},
      pages        = {e57912},
      year         = {2023},
      note         = {2023 Dec 6;24(12):e57912 / #EA:F170#LA:F170#},
      abstract     = {The risk of developing severe COVID-19 rises dramatically
                      with age. Schoolchildren are significantly less likely than
                      older people to die from SARS-CoV-2 infection, but the
                      molecular mechanisms underlying this age-dependence are
                      unknown. In primary infections, innate immunity is critical
                      due to the lack of immune memory. Children, in particular,
                      have a significantly stronger interferon response due to a
                      primed state of their airway epithelium. In single-cell
                      transcriptomes of nasal turbinates, we find increased
                      frequencies of immune cells and stronger cytokine-mediated
                      interactions with epithelial cells, resulting in increased
                      epithelial expression of viral sensors (RIG-I, MDA5) via
                      IRF1. In vitro, adolescent peripheral blood mononuclear
                      cells produce more cytokines, priming A549 cells for
                      stronger interferon responses to SARS-CoV-2. Taken together,
                      our findings suggest that increased numbers of immune cells
                      in the airways of children and enhanced cytokine-based
                      interactions with epithelial cells tune the setpoint of the
                      epithelial antiviral system. Our findings shed light on the
                      molecular basis of children's remarkable resistance to
                      COVID-19 and may suggest a novel concept for
                      immunoprophylactic treatments.},
      keywords     = {RIG-I like receptors (Other) / SARS-CoV-2 (Other) /
                      age-dependence of disease (Other) / children (Other) /
                      interferon response (Other)},
      cin          = {F170 / F171},
      ddc          = {570},
      cid          = {I:(DE-He78)F170-20160331 / I:(DE-He78)F171-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37818799},
      doi          = {10.15252/embr.202357912},
      url          = {https://inrepo02.dkfz.de/record/284644},
}