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| 001 | 284644 | ||
| 005 | 20240229155054.0 | ||
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| 037 | _ | _ | |a DKFZ-2023-02047 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Magalhães, Vladimir G |0 0000-0002-4593-3467 |b 0 |e First author |
| 245 | _ | _ | |a Immune-epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children. |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2023 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1702389983_9556 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2023 Dec 6;24(12):e57912 / #EA:F170#LA:F170# |
| 520 | _ | _ | |a The risk of developing severe COVID-19 rises dramatically with age. Schoolchildren are significantly less likely than older people to die from SARS-CoV-2 infection, but the molecular mechanisms underlying this age-dependence are unknown. In primary infections, innate immunity is critical due to the lack of immune memory. Children, in particular, have a significantly stronger interferon response due to a primed state of their airway epithelium. In single-cell transcriptomes of nasal turbinates, we find increased frequencies of immune cells and stronger cytokine-mediated interactions with epithelial cells, resulting in increased epithelial expression of viral sensors (RIG-I, MDA5) via IRF1. In vitro, adolescent peripheral blood mononuclear cells produce more cytokines, priming A549 cells for stronger interferon responses to SARS-CoV-2. Taken together, our findings suggest that increased numbers of immune cells in the airways of children and enhanced cytokine-based interactions with epithelial cells tune the setpoint of the epithelial antiviral system. Our findings shed light on the molecular basis of children's remarkable resistance to COVID-19 and may suggest a novel concept for immunoprophylactic treatments. |
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| 650 | _ | 7 | |a RIG-I like receptors |2 Other |
| 650 | _ | 7 | |a SARS-CoV-2 |2 Other |
| 650 | _ | 7 | |a age-dependence of disease |2 Other |
| 650 | _ | 7 | |a children |2 Other |
| 650 | _ | 7 | |a interferon response |2 Other |
| 700 | 1 | _ | |a Lukassen, Sören |b 1 |
| 700 | 1 | _ | |a Drechsler, Maike |0 P:(DE-He78)a931c8f45b0ade8be06a288982035fe3 |b 2 |u dkfz |
| 700 | 1 | _ | |a Loske, Jennifer |b 3 |
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| 700 | 1 | _ | |a Wüst, Sandra |0 P:(DE-He78)06a6077b0cfcb0f4890fb5f2543c43be |b 5 |u dkfz |
| 700 | 1 | _ | |a Jacobsen, Eva-Maria |0 0000-0003-4750-0136 |b 6 |
| 700 | 1 | _ | |a Röhmel, Jobst |b 7 |
| 700 | 1 | _ | |a Mall, Marcus A |0 0000-0002-4057-2199 |b 8 |
| 700 | 1 | _ | |a Debatin, Klaus-Michael |b 9 |
| 700 | 1 | _ | |a Eils, Roland |b 10 |
| 700 | 1 | _ | |a Autenrieth, Stella |0 P:(DE-He78)d3dbba28fe1239effd15962787cbc363 |b 11 |u dkfz |
| 700 | 1 | _ | |a Janda, Aleš |0 0000-0001-5604-8378 |b 12 |
| 700 | 1 | _ | |a Lehmann, Irina |b 13 |
| 700 | 1 | _ | |a Binder, Marco |0 P:(DE-He78)2fb2bd9048a3777dddc4cb89b115c187 |b 14 |e Last author |u dkfz |
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