TY  - JOUR
AU  - Biltekin, Fatih
AU  - Bäumer, Christian
AU  - Esser, Johannes
AU  - Ghanem, Osamah
AU  - Ozyigit, Gokhan
AU  - Timmermann, Beate
TI  - Preclinical Dosimetry for Small Animal Radiation Research in Proton Therapy: A Feasibility Study.
JO  - International journal of particle therapy
VL  - 10
IS  - 1
SN  - 2331-5180
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Particle Therapy Cooperative Group
M1  - DKFZ-2023-02055
SP  - 13 - 22
PY  - 2023
AB  - To evaluate the feasibility of the three-dimensional (3D) printed small animal phantoms in dosimetric verification of proton therapy for small animal radiation research.Two different phantoms were modeled using the computed-tomography dataset of real rat and tumor-bearing mouse, retrospectively. Rat phantoms were designed to accommodate both EBT3 film and ionization chamber. A subcutaneous tumor-bearing mouse phantom was only modified to accommodate film dosimetry. All phantoms were printed using polylactic-acid (PLA) filament. Optimal printing parameters were set to create tissue-equivalent material. Then, proton therapy plans for different anatomical targets, including whole brain and total lung irradiation in the rat phantom and the subcutaneous tumor model in the mouse phantom, were created using the pencil-beam scanning technique. Point dose and film dosimetry measurements were performed using 3D-printed phantoms. In addition, all phantoms were analyzed in terms of printing accuracy and uniformity.Three-dimensionally printed phantoms had excellent uniformity over the external body, and printing accuracy was within 0.5 mm. According to our findings, two-dimensional dosimetry with EBT3 showed acceptable levels of γ passing rate for all measurements except for whole brain irradiation (γ passing rate, 89.8
KW  - 3D printer (Other)
KW  - preclinical dosimetry (Other)
KW  - proton therapy (Other)
KW  - small animal phantom (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37823014
C2  - pmc:PMC10563666
DO  - DOI:10.14338/IJPT-22-00035.1
UR  - https://inrepo02.dkfz.de/record/284654
ER  -