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@ARTICLE{Biltekin:284654,
      author       = {F. Biltekin and C. Bäumer$^*$ and J. Esser and O. Ghanem
                      and G. Ozyigit and B. Timmermann$^*$},
      title        = {{P}reclinical {D}osimetry for {S}mall {A}nimal {R}adiation
                      {R}esearch in {P}roton {T}herapy: {A} {F}easibility
                      {S}tudy.},
      journal      = {International journal of particle therapy},
      volume       = {10},
      number       = {1},
      issn         = {2331-5180},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Particle Therapy Cooperative Group},
      reportid     = {DKFZ-2023-02055},
      pages        = {13 - 22},
      year         = {2023},
      abstract     = {To evaluate the feasibility of the three-dimensional (3D)
                      printed small animal phantoms in dosimetric verification of
                      proton therapy for small animal radiation research.Two
                      different phantoms were modeled using the
                      computed-tomography dataset of real rat and tumor-bearing
                      mouse, retrospectively. Rat phantoms were designed to
                      accommodate both EBT3 film and ionization chamber. A
                      subcutaneous tumor-bearing mouse phantom was only modified
                      to accommodate film dosimetry. All phantoms were printed
                      using polylactic-acid (PLA) filament. Optimal printing
                      parameters were set to create tissue-equivalent material.
                      Then, proton therapy plans for different anatomical targets,
                      including whole brain and total lung irradiation in the rat
                      phantom and the subcutaneous tumor model in the mouse
                      phantom, were created using the pencil-beam scanning
                      technique. Point dose and film dosimetry measurements were
                      performed using 3D-printed phantoms. In addition, all
                      phantoms were analyzed in terms of printing accuracy and
                      uniformity.Three-dimensionally printed phantoms had
                      excellent uniformity over the external body, and printing
                      accuracy was within 0.5 mm. According to our findings,
                      two-dimensional dosimetry with EBT3 showed acceptable levels
                      of γ passing rate for all measurements except for whole
                      brain irradiation (γ passing rate, $89.8\%).$ In terms of
                      point dose analysis, a good agreement $(<0.1\%)$ was found
                      between the measured and calculated point doses for all
                      anatomical targets.Three-dimensionally printed small animal
                      phantoms show great potential for dosimetric verifications
                      of clinical proton therapy for small animal radiation
                      research.},
      keywords     = {3D printer (Other) / preclinical dosimetry (Other) / proton
                      therapy (Other) / small animal phantom (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37823014},
      pmc          = {pmc:PMC10563666},
      doi          = {10.14338/IJPT-22-00035.1},
      url          = {https://inrepo02.dkfz.de/record/284654},
}