%0 Journal Article
%A Sherry, Alexander D
%A Msaouel, Pavlos
%A McCaw, Zachary R
%A Abi Jaoude, Joseph
%A Hsu, Eric J
%A Kouzy, Ramez
%A Patel, Roshal
%A Yang, Yumeng
%A Lin, Timothy A
%A Taniguchi, Cullen M
%A Rödel, Claus
%A Fokas, Emmanouil
%A Tang, Chad
%A Fuller, Clifton David
%A Minsky, Bruce
%A Meirson, Tomer
%A Sun, Ryan
%A Ludmir, Ethan B
%T Prevalence and implications of significance testing for baseline covariate imbalance in randomised cancer clinical trials: The Table 1 Fallacy.
%J European journal of cancer
%V 194
%@ 0014-2964
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2023-02058
%P 113357
%D 2023
%X The 'Table 1 Fallacy' refers to the unsound use of significance testing for comparing the distributions of baseline variables between randomised groups to draw erroneous conclusions about balance or imbalance. We performed a cross-sectional study of the Table 1 Fallacy in phase III oncology trials.From ClinicalTrials.gov, 1877 randomised trials were screened. Multivariable logistic regressions evaluated predictors of the Table 1 Fallacy.A total of 765 randomised controlled trials involving 553,405 patients were analysed. The Table 1 Fallacy was observed in 25
%K Covariate imbalance (Other)
%K Oncology (Other)
%K Phase III (Other)
%K Randomised controlled trials (Other)
%K Significance testing for baseline characteristics (Other)
%K Table 1 Fallacy (Other)
%K Testing for baseline differences (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37827064
%R 10.1016/j.ejca.2023.113357
%U https://inrepo02.dkfz.de/record/284657