TY  - JOUR
AU  - Sherry, Alexander D
AU  - Msaouel, Pavlos
AU  - McCaw, Zachary R
AU  - Abi Jaoude, Joseph
AU  - Hsu, Eric J
AU  - Kouzy, Ramez
AU  - Patel, Roshal
AU  - Yang, Yumeng
AU  - Lin, Timothy A
AU  - Taniguchi, Cullen M
AU  - Rödel, Claus
AU  - Fokas, Emmanouil
AU  - Tang, Chad
AU  - Fuller, Clifton David
AU  - Minsky, Bruce
AU  - Meirson, Tomer
AU  - Sun, Ryan
AU  - Ludmir, Ethan B
TI  - Prevalence and implications of significance testing for baseline covariate imbalance in randomised cancer clinical trials: The Table 1 Fallacy.
JO  - European journal of cancer
VL  - 194
SN  - 0014-2964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-02058
SP  - 113357
PY  - 2023
AB  - The 'Table 1 Fallacy' refers to the unsound use of significance testing for comparing the distributions of baseline variables between randomised groups to draw erroneous conclusions about balance or imbalance. We performed a cross-sectional study of the Table 1 Fallacy in phase III oncology trials.From ClinicalTrials.gov, 1877 randomised trials were screened. Multivariable logistic regressions evaluated predictors of the Table 1 Fallacy.A total of 765 randomised controlled trials involving 553,405 patients were analysed. The Table 1 Fallacy was observed in 25
KW  - Covariate imbalance (Other)
KW  - Oncology (Other)
KW  - Phase III (Other)
KW  - Randomised controlled trials (Other)
KW  - Significance testing for baseline characteristics (Other)
KW  - Table 1 Fallacy (Other)
KW  - Testing for baseline differences (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37827064
DO  - DOI:10.1016/j.ejca.2023.113357
UR  - https://inrepo02.dkfz.de/record/284657
ER  -