TY  - JOUR
AU  - Ciobanu-Caraus, Olga
AU  - Czech, Thomas
AU  - Peyrl, Andreas
AU  - Haberler, Christine
AU  - Kasprian, Gregor
AU  - Furtner, Julia
AU  - Kool, Marcel
AU  - Sill, Martin
AU  - Frischer, Josa M
AU  - Cho, Anna
AU  - Slavc, Irene
AU  - Rössler, Karl
AU  - Gojo, Johannes
AU  - Dorfer, Christian
TI  - The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups.
JO  - Cancers
VL  - 15
IS  - 19
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-02065
SP  - 4877
PY  - 2023
AB  - Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, 'correct' prediction of molecular groups was feasible in 20
KW  - MB (Other)
KW  - molecular group (Other)
KW  - neurosurgery (Other)
KW  - origin (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37835571
C2  - pmc:PMC10571892
DO  - DOI:10.3390/cancers15194877
UR  - https://inrepo02.dkfz.de/record/284754
ER  -