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@ARTICLE{CiobanuCaraus:284754,
      author       = {O. Ciobanu-Caraus and T. Czech and A. Peyrl and C. Haberler
                      and G. Kasprian and J. Furtner and M. Kool$^*$ and M.
                      Sill$^*$ and J. M. Frischer and A. Cho and I. Slavc and K.
                      Rössler and J. Gojo and C. Dorfer},
      title        = {{T}he {S}ite of {O}rigin of {M}edulloblastoma: {S}urgical
                      {O}bservations {C}orrelated to {M}olecular {G}roups.},
      journal      = {Cancers},
      volume       = {15},
      number       = {19},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-02065},
      pages        = {4877},
      year         = {2023},
      abstract     = {Developmental gene expression data from medulloblastoma
                      (MB) suggest that WNT-MB originates from the region of the
                      embryonic lower rhombic lip (LRL), whereas SHH-MB and
                      non-WNT/non-SHH MB arise from cerebellar precursor matrix
                      regions. This study aimed to analyze detailed intraoperative
                      data with regard to the site of origin (STO) and compare
                      these findings with the hypothesized regions of origin
                      associated with the molecular group. A review of the
                      institutional database identified 58 out of 72 pediatric
                      patients who were operated for an MB at our department
                      between 1996 and 2020 that had a detailed operative report
                      and a surgical video as well as clinical and genetic
                      classification data available for analysis. The STO was
                      assessed based on intraoperative findings. Using the
                      intraoperatively defined STO, 'correct' prediction of
                      molecular groups was feasible in $20\%$ of WNT-MB, $60\%$ of
                      SHH-MB and $71\%$ of non-WNT/non-SHH MB. The positive
                      predictive values of the neurosurgical inspection to detect
                      the molecular group were 0.21 $(95\%$ CI 0.08-0.48) for
                      WNT-MB, 0.86 $(95\%$ CI 0.49-0.97) for SHH-MB and 0.73
                      $(95\%$ CI 0.57-0.85) for non-WNT/non-SHH MB. The present
                      study demonstrated a limited predictive value of the
                      intraoperatively observed STO for the prediction of the
                      molecular group of MB.},
      keywords     = {MB (Other) / molecular group (Other) / neurosurgery (Other)
                      / origin (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37835571},
      pmc          = {pmc:PMC10571892},
      doi          = {10.3390/cancers15194877},
      url          = {https://inrepo02.dkfz.de/record/284754},
}