%0 Journal Article
%A Nimptsch, Katharina
%A Aleksandrova, Krasimira
%A Pham, Thu Thi
%A Papadimitriou, Nikos
%A Janke, Jürgen
%A Christakoudi, Sofia
%A Heath, Alicia
%A Olsen, Anja
%A Tjønneland, Anne
%A Schulze, Matthias B
%A Katzke, Verena
%A Kaaks, Rudolf
%A van Guelpen, Bethany
%A Harbs, Justin
%A Palli, Domenico
%A Macciotta, Alessandra
%A Pasanisi, Fabrizio
%A Yohar, Sandra Milena Colorado
%A Guevara, Marcela
%A Amiano, Pilar
%A Grioni, Sara
%A Jakszyn, Paula Gabriela
%A Figueiredo, Jane C
%A Samadder, N Jewel
%A Li, Christopher I
%A Moreno, Victor
%A Potter, John D
%A Schoen, Robert E
%A Um, Caroline Y
%A Weiderpass, Elisabete
%A Jenab, Mazda
%A Gunter, Marc J
%A Pischon, Tobias
%T Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.
%J BMC medicine
%V 21
%N 1
%@ 1741-7015
%C Heidelberg [u.a.]
%I Springer
%M DKFZ-2023-02078
%P 391
%D 2023
%X Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach.The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry.In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95
%K Colorectal cancer (Other)
%K FABP-4 (Other)
%K Mendelian randomization (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37833736
%2 pmc:PMC10576353
%R 10.1186/s12916-023-03104-1
%U https://inrepo02.dkfz.de/record/284767