TY  - JOUR
AU  - Nimptsch, Katharina
AU  - Aleksandrova, Krasimira
AU  - Pham, Thu Thi
AU  - Papadimitriou, Nikos
AU  - Janke, Jürgen
AU  - Christakoudi, Sofia
AU  - Heath, Alicia
AU  - Olsen, Anja
AU  - Tjønneland, Anne
AU  - Schulze, Matthias B
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - van Guelpen, Bethany
AU  - Harbs, Justin
AU  - Palli, Domenico
AU  - Macciotta, Alessandra
AU  - Pasanisi, Fabrizio
AU  - Yohar, Sandra Milena Colorado
AU  - Guevara, Marcela
AU  - Amiano, Pilar
AU  - Grioni, Sara
AU  - Jakszyn, Paula Gabriela
AU  - Figueiredo, Jane C
AU  - Samadder, N Jewel
AU  - Li, Christopher I
AU  - Moreno, Victor
AU  - Potter, John D
AU  - Schoen, Robert E
AU  - Um, Caroline Y
AU  - Weiderpass, Elisabete
AU  - Jenab, Mazda
AU  - Gunter, Marc J
AU  - Pischon, Tobias
TI  - Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.
JO  - BMC medicine
VL  - 21
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2023-02078
SP  - 391
PY  - 2023
AB  - Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach.The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry.In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95
KW  - Colorectal cancer (Other)
KW  - FABP-4 (Other)
KW  - Mendelian randomization (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37833736
C2  - pmc:PMC10576353
DO  - DOI:10.1186/s12916-023-03104-1
UR  - https://inrepo02.dkfz.de/record/284767
ER  -