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@ARTICLE{Nimptsch:284767,
      author       = {K. Nimptsch and K. Aleksandrova and T. T. Pham and N.
                      Papadimitriou and J. Janke and S. Christakoudi and A. Heath
                      and A. Olsen and A. Tjønneland and M. B. Schulze and V.
                      Katzke$^*$ and R. Kaaks$^*$ and B. van Guelpen and J. Harbs
                      and D. Palli and A. Macciotta and F. Pasanisi and S. M. C.
                      Yohar and M. Guevara and P. Amiano and S. Grioni and P. G.
                      Jakszyn and J. C. Figueiredo and N. J. Samadder and C. I. Li
                      and V. Moreno and J. D. Potter and R. E. Schoen and C. Y. Um
                      and E. Weiderpass and M. Jenab and M. J. Gunter and T.
                      Pischon},
      title        = {{P}rospective and {M}endelian randomization analyses on the
                      association of circulating fatty acid binding protein 4
                      ({FABP}-4) and risk of colorectal cancer.},
      journal      = {BMC medicine},
      volume       = {21},
      number       = {1},
      issn         = {1741-7015},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-02078},
      pages        = {391},
      year         = {2023},
      abstract     = {Fatty acid binding protein 4 (FABP-4) is a lipid-binding
                      adipokine upregulated in obesity, which may facilitate fatty
                      acid supply for tumor growth and promote insulin resistance
                      and inflammation and may thus play a role in colorectal
                      cancer (CRC) development. We aimed to investigate the
                      association between circulating FABP-4 and CRC and to assess
                      potential causality using a Mendelian randomization (MR)
                      approach.The association between pre-diagnostic plasma
                      measurements of FABP-4 and CRC risk was investigated in a
                      nested case-control study in 1324 CRC cases and the same
                      number of matched controls within the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) cohort. A
                      two-sample Mendelian randomization study was conducted based
                      on three genetic variants (1 cis, 2 trans) associated with
                      circulating FABP-4 identified in a published genome-wide
                      association study (discovery n = 20,436) and data from
                      58,131 CRC cases and 67,347 controls in the Genetics and
                      Epidemiology of Colorectal Cancer Consortium, Colorectal
                      Cancer Transdisciplinary Study, and Colon Cancer Family
                      Registry.In conditional logistic regression models adjusted
                      for potential confounders including body size, the estimated
                      relative risk, RR $(95\%$ confidence interval, CI) per one
                      standard deviation, SD (8.9 ng/mL) higher FABP-4
                      concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80,
                      1.13) in men and 1.09 (0.95, 1.25) in women. Genetically
                      determined higher FABP-4 was not associated with colorectal
                      cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall,
                      1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women).
                      However, in a cis-MR approach, a statistically significant
                      association was observed in women (RR 1.56, 1.09, 2.23) but
                      not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71,
                      1.37).Taken together, these analyses provide no support for
                      a causal role of circulating FABP-4 in the development of
                      CRC, although the cis-MR provides some evidence for a
                      positive association in women, which may deserve to be
                      investigated further.},
      keywords     = {Colorectal cancer (Other) / FABP-4 (Other) / Mendelian
                      randomization (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37833736},
      pmc          = {pmc:PMC10576353},
      doi          = {10.1186/s12916-023-03104-1},
      url          = {https://inrepo02.dkfz.de/record/284767},
}