TY  - JOUR
AU  - Sommerhäuser, Greta
AU  - Karthaus, Meinolf
AU  - Kurreck, Annika
AU  - Ballhausen, Alexej
AU  - Meyer-Knees, Johanna W
AU  - Fruehauf, Stefan
AU  - Graeven, Ullrich
AU  - Mueller, Lothar
AU  - Koenig, Alexander O
AU  - Weikersthal, Ludwig Fischer V
AU  - Goekkurt, Eray
AU  - Haas, Siegfried
AU  - Stahler, Arndt
AU  - Heinemann, Volker
AU  - Held, Swantje
AU  - Alig, Annabel H S
AU  - Kasper-Virchow, Stefan
AU  - Stintzing, Sebastian
AU  - Trarbach, Tanja
AU  - Modest, Dominik P
TI  - Prognostic and predictive impact of metastatic organ involvement on maintenance therapy in advanced metastatic colorectal cancer: Subgroup analysis of patients treated within the PanaMa trial (AIO KRK 0212).
JO  - International journal of cancer
VL  - 154
IS  - 5
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2023-02086
SP  - 863-872
PY  - 2024
N1  - 2024 Mar 1;154(5):863-872
AB  - Despite molecular selection, patients (pts) with RAS wildtype mCRC represent a heterogeneous population including diversity in metastatic spread. We investigated metastatic patterns for their prognostic and predictive impact on maintenance therapy with 5-fluorouracil/folinic acid ± panitumumab. The study population was stratified according to (1) number of involved metastatic sites (single vs multiple organ metastasis), liver-limited disease vs (2) liver metastasis plus one additional site, and (3) vs liver metastasis plus ≥two additional sites. Kaplan-Meier method and Cox regressions were used to correlate efficacy endpoints. Single organ metastasis was observed in 133 pts (53.6
KW  - maintenance therapy (Other)
KW  - metastases (Other)
KW  - metastatic colorectal cancer (Other)
KW  - panitumumab (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37840339
DO  - DOI:10.1002/ijc.34760
UR  - https://inrepo02.dkfz.de/record/284775
ER  -