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@ARTICLE{Sommerhuser:284775,
      author       = {G. Sommerhäuser and M. Karthaus and A. Kurreck and A.
                      Ballhausen and J. W. Meyer-Knees and S. Fruehauf and U.
                      Graeven and L. Mueller and A. O. Koenig and L. F. V.
                      Weikersthal and E. Goekkurt and S. Haas and A. Stahler and
                      V. Heinemann$^*$ and S. Held and A. H. S. Alig and S.
                      Kasper-Virchow$^*$ and S. Stintzing$^*$ and T. Trarbach and
                      D. P. Modest$^*$},
      title        = {{P}rognostic and predictive impact of metastatic organ
                      involvement on maintenance therapy in advanced metastatic
                      colorectal cancer: {S}ubgroup analysis of patients treated
                      within the {P}ana{M}a trial ({AIO} {KRK} 0212).},
      journal      = {International journal of cancer},
      volume       = {154},
      number       = {5},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-02086},
      pages        = {863-872},
      year         = {2024},
      note         = {2024 Mar 1;154(5):863-872},
      abstract     = {Despite molecular selection, patients (pts) with RAS
                      wildtype mCRC represent a heterogeneous population including
                      diversity in metastatic spread. We investigated metastatic
                      patterns for their prognostic and predictive impact on
                      maintenance therapy with 5-fluorouracil/folinic acid ±
                      panitumumab. The study population was stratified according
                      to (1) number of involved metastatic sites (single vs
                      multiple organ metastasis), liver-limited disease vs (2)
                      liver metastasis plus one additional site, and (3) vs liver
                      metastasis plus ≥two additional sites. Kaplan-Meier method
                      and Cox regressions were used to correlate efficacy
                      endpoints. Single organ metastasis was observed in 133 pts
                      $(53.6\%)$ with 102 pts $(41.1\%)$ presenting with
                      liver-limited disease, while multiple organ metastases were
                      reported in 114 pts (46.0). Multiple compared to single
                      organ metastases were associated with less favorable PFS (HR
                      1.48, $95\%$ CI 1.13-1.93; P = .004) and OS (HR 1.37, $95\%$
                      CI 0.98-1.93; P = .068) of maintenance therapy. While
                      metastatic spread involving one additional extrahepatic site
                      was not associated with clearly impaired survival compared
                      to liver-limited disease, pts with liver metastasis plus
                      ≥two additional sites demonstrated less favorable PFS (HR
                      1.92, $95\%$ CI 1.30-2.83; P < .001), and OS (HR 2.38,
                      $95\%$ CI 1.51-3.76; P < .001) of maintenance therapy.
                      Pmab-containing maintenance therapy appeared active in both
                      pts with multiple (HR 0.58; $95\%$ CI, 0.39-0.86; P = .006)
                      as well as to a lesser numerical extent in pts with single
                      organ metastasis (HR 0.83; $95\%$ CI, 0.57-1.21; P = .332;
                      Interaction P = .183). These data may support clinical
                      decisions when EGFR-based maintenance therapy is
                      considered.},
      keywords     = {maintenance therapy (Other) / metastases (Other) /
                      metastatic colorectal cancer (Other) / panitumumab (Other)},
      cin          = {BE01 / MU01 / ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)MU01-20160331 /
                      I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37840339},
      doi          = {10.1002/ijc.34760},
      url          = {https://inrepo02.dkfz.de/record/284775},
}