TY  - JOUR
AU  - Rank, Luisa
AU  - Dogan, Ozan
AU  - Kopp, Benedikt
AU  - Mein, Stewart
AU  - Verona-Rinati, Gianluca
AU  - Kranzer, Rafael
AU  - Marinelli, Marco
AU  - Mairani, Andrea
AU  - Tessonnier, Thomas
TI  - Development and benchmarking of a dose rate engine for raster-scanned FLASH helium ions.
JO  - Medical physics
VL  - 51
IS  - 3
SN  - 0094-2405
CY  - College Park, Md.
PB  - AAPM
M1  - DKFZ-2023-02106
SP  - 2251-2262
PY  - 2024
N1  - #LA:E210# / 2024 Mar;51(3):2251-2262
AB  - Radiotherapy with charged particles at high dose and ultra-high dose rate (uHDR) is a promising technique to further increase the therapeutic index of patient treatments. Dose rate is a key quantity to predict the so-called FLASH effect at uHDR settings. However, recent works introduced varying calculation models to report dose rate, which is susceptible to the delivery method, scanning path (in active beam delivery) and beam intensity.This work introduces an analytical dose rate calculation engine for raster scanned charged particle beams that is able to predict dose rate from the irradiation plan and recorded beam intensity. The importance of standardized dose rate calculation methods is explored here.Dose is obtained with an analytical pencil beam algorithm, using pre-calculated databases for integrated depth dose distributions and lateral penumbra. Dose rate is then calculated by combining dose information with the respective particle fluence (i.e., time information) using three dose-rate-calculation models (mean, instantaneous, and threshold-based). Dose rate predictions for all three models are compared to uHDR helium ion beam (145.7 MeV/u, range in water of approximatively 14.6 cm) measurements performed at the Heidelberg Ion Beam Therapy Center (HIT) with a diamond-detector prototype. Three scanning patterns (scanned or snake-like) and four field sizes are used to investigate the dose rate differences.Dose rate measurements were in good agreement with in-silico generated distributions using the here introduced engine. Relative differences in dose rate were below 10
KW  - engine (Other)
KW  - flash (Other)
KW  - helium ions (Other)
KW  - radiotherapy (Other)
KW  - ultra high dose rate (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37847027
DO  - DOI:10.1002/mp.16793
UR  - https://inrepo02.dkfz.de/record/284803
ER  -