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@ARTICLE{Stingu:284810,
      author       = {E. Stingu and J.-M. Dobrowolski and P. Bombach and D. Nann
                      and S. Singer and M. Horger and U. M. Lauer$^*$ and L.
                      Zender$^*$ and C. Hinterleitner and M. Hinterleitner},
      title        = {{M}yasthenia gravis as initial presentation of a pancreatic
                      neuroendocrine tumor: {A} case report.},
      journal      = {Experimental and Therapeutic Medicine},
      volume       = {26},
      number       = {5},
      issn         = {1792-0981},
      address      = {Athens},
      publisher    = {Spandidos Publ.},
      reportid     = {DKFZ-2023-02109},
      pages        = {523},
      year         = {2023},
      abstract     = {Myasthenia gravis (MG) is a heterogeneous autoimmune
                      disease, which is characterized by a postsynaptic
                      neuromuscular transmission defect, with antibodies directly
                      targeting the acetylcholine receptor (AChR) or other
                      structural proteins of the neuromuscular junction. The
                      majority of MG cases are associated with thymic pathologies,
                      including thymoma, thyroiditis, autoimmune diseases or
                      malignant hematologic neoplasia. The present study reported
                      a rare case of AChR-positive and late-onset ocular MG, which
                      rapidly progressed to a generalized myasthenic syndrome as
                      an initial presentation of a pancreatic neuroendocrine
                      neoplasia (pNEN). Following complete surgical resection of
                      the pNEN, the myasthenic syndrome was improved and the
                      anti-AChR antibody titers were reduced. It has been reported
                      that MG is a paraneoplastic syndrome in thymic neoplasms and
                      less common in hematologic malignancies. However, currently,
                      only few cases of MG as initial presentation of a solid
                      tumor, and more particular of a neuroendocrine neoplasm,
                      have been reported in the literature. In conclusion,
                      surveillance for extrathymic solid malignancies in newly
                      diagnosed patients with MG could promote the early diagnosis
                      of associated tumor diseases.},
      keywords     = {acetylcholine receptor (Other) / chromogranin A (Other) /
                      myasthenia gravis (Other) / pancreatic neuroendocrine
                      neoplasia (Other) / paraneoplastic syndrome (Other) / solid
                      tumor (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37854502},
      pmc          = {pmc:PMC10580239},
      doi          = {10.3892/etm.2023.12222},
      url          = {https://inrepo02.dkfz.de/record/284810},
}