% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hoppner:284822,
      author       = {J. Hoppner and L. van Genabith and T. Hielscher$^*$ and U.
                      Heger and L. Sperling and T. Colbatzky and E. Gutjahr and M.
                      Lang and T. Pausch and A.-M. Spektor and F. M. Glatting$^*$
                      and J. Liermann and T. Hackert and C. Kratochwil and F. L.
                      Giesel and U. Haberkorn$^*$ and M. Röhrich},
      title        = {{C}omparison of early and late 68{G}a-{FAPI}-46-{PET} in 33
                      patients with possible recurrence of pancreatic ductal
                      adenocarcinomas.},
      journal      = {Scientific reports},
      volume       = {13},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2023-02118},
      pages        = {17848},
      year         = {2023},
      abstract     = {Positron emission tomography with 68Gallium (68Ga) labeled
                      inhibitors of fibroblast activation protein (68Ga-FAPI-PET)
                      is a promising imaging technique for patients with recurrent
                      pancreatic ductal adenocarcinomas (PDAC). To date, it is not
                      clear if different acquisition timepoints for 68Ga-FAPI-PET
                      may result in comparable imaging information and if
                      repetitive 68Ga-FAPI-PET imaging may add diagnostic value to
                      single timepoint acquisition for recurrent PDAC. Here we
                      analyzed retrospectively early (20 min p.i.) and late (60
                      min p.i.) 68Ga-FAPI-PET imaging using FAPI-46 of 33 patients
                      with possible recurrence of PDAC concerning detection rates
                      and uptake over time of local recurrences, metastases,
                      inflammatory lesions of the pancreas, cholestatic lesions of
                      the liver and reactive tissue. 33 patients with
                      histologically confirmed PDAC after complete or partial
                      resection of the pancreas and possible recurrence were
                      examined by 68Ga-FAPI-46-PET acquired 20- and 60-min post
                      injection (p.i.) of the radiotracer. FAPI-positive lesions
                      were classified as local recurrences, metastases,
                      inflammatory lesions of the pancreas (ILP), cholestatic
                      lesions of the liver and reactive tissue based on histology,
                      PET- and CT-morphology and clinical information. Lesions
                      were contoured, and standardized uptake values (SUVmax and
                      SUVmean) and target-to-background ratios (TBR) were analyzed
                      for both acquisition timepoints. In total, 152 FAPI-positive
                      lesions (22 local relapses, 47 metastases, 26 inflammatory
                      lesions of the pancreas, 28 reactive tissues, and 29
                      cholestatic lesions) were detected. Detection rates for the
                      early and late acquisition of 68Ga-FAPI-46-PET were almost
                      identical except cholestatic lesions, which showed a higher
                      detection rate at early imaging. SUV parameters and TBRs of
                      ILP significantly decreased over time. Cholestatic lesions
                      showed a tendency towards decreasing uptake. All other types
                      of lesions showed relatively stable uptake over time. Early
                      and late acquisition of 68Ga-FAPI-PET results in comparable
                      imaging information in patients with possible recurrence of
                      PDAC. Two timepoint imaging offers additional diagnostic
                      potential concerning differential diagnoses.},
      cin          = {C060 / E055 / E060},
      ddc          = {600},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E055-20160331 /
                      I:(DE-He78)E060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37857656},
      doi          = {10.1038/s41598-023-43049-2},
      url          = {https://inrepo02.dkfz.de/record/284822},
}