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@ARTICLE{Sprave:284827,
      author       = {T. Sprave$^*$ and M. Pfaffenlehner and R. Stoian$^*$ and E.
                      Christofi$^*$ and A. Rühle$^*$ and D. Zöller and A.
                      Fabian$^*$ and H. Fahrner and H. Binder and H. Schäfer$^*$
                      and E. Gkika$^*$ and A.-L. Grosu$^*$ and F. Heinemann and N.
                      Nicolay$^*$},
      title        = {{A}pp-{C}ontrolled {T}reatment {M}onitoring and {S}upport
                      for {P}atients {W}ith {H}ead and {N}eck {C}ancer
                      {U}ndergoing {R}adiotherapy: {R}esults {F}rom a
                      {P}rospective {R}andomized {C}ontrolled {T}rial.},
      journal      = {Journal of medical internet research},
      volume       = {25},
      issn         = {1439-4456},
      address      = {Richmond, Va.},
      publisher    = {Healthcare World},
      reportid     = {DKFZ-2023-02123},
      pages        = {e46189},
      year         = {2023},
      note         = {#LA:E055#},
      abstract     = {Head and neck cancers (HNCs) are very common malignancies,
                      and treatment often requires multimodal approaches,
                      including radiotherapy and chemotherapy. Patients with HNC
                      often display a high symptom burden, both due to the disease
                      itself and the adverse effects of the multimodal therapy.
                      Close telemonitoring of symptoms and quality of life during
                      the course of treatment may help to identify those patients
                      requiring early medical support.The App-Controlled Treatment
                      Monitoring and Support for Patients With Head and Neck
                      Cancer (APCOT) trial aimed to investigate the feasibility of
                      integrating electronic patient-reported outcomes (ePROs) in
                      the treatment surveillance pathway of patients with HNC
                      during the course of their radiotherapy. Additionally, the
                      influence of app-based ePRO monitoring on global and
                      disease-specific quality of life and patient satisfaction
                      with treatment was assessed.Patients undergoing radiotherapy
                      for histologically proven HNCs at the Department of
                      Radiation Oncology, University Medical Center Freiburg,
                      Germany, were enrolled in this trial and monitored by weekly
                      physician appointments. Patients were randomized between
                      additional ePRO monitoring on each treatment day or
                      standard-of-care monitoring. Feasibility of ePRO monitoring
                      was defined as $≥80\%$ of enrolled patients answering
                      $≥80\%$ of their daily app-based questions. Quality of
                      life and patient satisfaction were assessed by the European
                      Organisation for Research and Treatment of Cancer Core
                      Quality of Life Questionnaire (QLQ-C30), the head and neck
                      cancer module $(H\&N35),$ and the validated Patient
                      Satisfaction Questionnaire Short Form (PSQ-18) at the
                      completion of treatment and compared between trial arms.A
                      total of 100 patients were enrolled in this trial, and 93
                      patients were evaluable. All patients $(100\%)$ in the
                      experimental arm answered $≥80\%$ of the ePRO questions
                      during treatment, reaching the predefined threshold for the
                      feasibility of ePRO monitoring (P<.001 in the binomial
                      test). No clinical or patient-specific factor was found to
                      influence feasibility. Global health and most domains of the
                      general quality of life were comparable between trial arms,
                      but an increased HNC-specific symptom burden was reported by
                      patients undergoing ePRO surveillance. ePRO monitoring
                      resulted in improved patient satisfaction regarding
                      interpersonal manners (P=.01), financial aspects (P=.01),
                      and time spent with a doctor (P=.01).This trial demonstrated
                      the feasibility of incorporating daily app-based ePRO
                      surveillance for patients with HNC undergoing radiotherapy.
                      Our data, for the first time, demonstrate that
                      telemonitoring in this setting led to increased reporting of
                      HNC-specific symptom burden and significantly improved
                      several domains of patient satisfaction. Further analyses
                      are needed to assess whether our findings hold true outside
                      the context of a clinical trial.German Clinical Trials
                      Register DRKS00020491;
                      https://drks.de/search/en/trial/DRKS00020491.},
      keywords     = {HNSCC (Other) / PROM (Other) / RCT (Other) / app-based
                      (Other) / cancer (Other) / feasibility (Other) / head
                      (Other) / head and neck cancer (Other) / head and neck
                      squamous cell carcinoma (Other) / mHealth (Other) / mobile
                      app (Other) / mobile health (Other) / neck (Other) /
                      oncology (Other) / outcome measure (Other) / patient
                      reported (Other) / patient surveillance (Other) /
                      patient-reported outcome measure (Other) / quality of life
                      (Other) / radiation (Other) / radiotherapy (Other) /
                      randomized controlled trial (Other) / satisfaction (Other) /
                      treatment surveillance (Other)},
      cin          = {FR01 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37856185},
      doi          = {10.2196/46189},
      url          = {https://inrepo02.dkfz.de/record/284827},
}