TY  - JOUR
AU  - Boschheidgen, Matthias
AU  - Albers, Peter
AU  - Schlemmer, Heinz-Peter
AU  - Hellms, Susanne
AU  - Bonekamp, David
AU  - Sauter, Andreas
AU  - Hadaschik, Boris
AU  - Krilaviciute, Agne
AU  - Radtke, Jan Philipp
AU  - Seibold, Petra
AU  - Lakes, Jale
AU  - Arsov, Christian
AU  - Gschwend, Jürgen E
AU  - Herkommer, Kathleen
AU  - Makowski, Marcus
AU  - Kuczyk, Markus A
AU  - Wacker, Frank
AU  - Harke, Nina
AU  - Debus, Jürgen
AU  - Körber, Stefan A
AU  - Benner, Axel
AU  - Kristiansen, Glen
AU  - Giesel, Frederik L
AU  - Antoch, Gerald
AU  - Kaaks, Rudolf
AU  - Becker, Nikolaus
AU  - Schimmöller, Lars
TI  - Multiparametric Magnetic Resonance Imaging in Prostate Cancer Screening at the Age of 45 Years: Results from the First Screening Round of the PROBASE Trial.
JO  - European urology
VL  - 85
IS  - 2
SN  - 0302-2838
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-02132
SP  - 105-111
PY  - 2024
N1  - 2024 Feb;85(2):105-111
AB  - Magnetic resonance imaging (MRI) has been suggested as a tool for guiding biopsy recommendations in prostate cancer (PC) screening.To determine the performance of multiparametric MRI (mpMRI) in young men at age 45 yr who participated in a PC screening trial (PROBASE) on the basis of baseline prostate-specific antigen (PSA).Participants with confirmed PSA ≥3 ng/ml were offered mpMRI followed by MRI/transrectal ultrasound fusion biopsy (FBx) with targeted and systematic cores. mpMRI scans from the first screening round for men randomised to an immediate PSA test in PROBASE were evaluated by local readers and then by two reference radiologists (experience >10 000 prostate MRI examinations) blinded to the histopathology. The PROBASE trial is registered as ISRCTN37591328 OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The local and reference Prostate Imaging-Data and Reporting System (PI-RADS) scores were compared, and the sensitivity, negative predictive value (NPV), and accuracy were calculated for both readings for different cutoffs (PI-RADS 3 vs 4).Of 186 participants, 114 underwent mpMRI and FBx. PC was detected in 47 (41
KW  - Magnetic resonance imaging, Interventional (Other)
KW  - Multiparametric magnetic resonance imaging (Other)
KW  - Prostatic neoplasms (Other)
KW  - Screening (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37863727
DO  - DOI:10.1016/j.eururo.2023.09.027
UR  - https://inrepo02.dkfz.de/record/284932
ER  -