TY  - JOUR
AU  - Zhao, Binghao
AU  - Kilian, Michael
AU  - Bunse, Theresa
AU  - Platten, Michael
AU  - Bunse, Lukas
TI  - Tumor-reactive T helper cells in the context of vaccination against glioma.
JO  - Cancer cell
VL  - 41
IS  - 11
SN  - 1535-6108
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2023-02137
SP  - 1829-1834
PY  - 2023
N1  - #EA:D170#LA:D170# / 2023 Nov 13;41(11):1829-1834 / HI-TRON / review email KST
AB  - With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision antitumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs.
LB  - PUB:(DE-HGF)16
C6  - pmid:37863064
DO  - DOI:10.1016/j.ccell.2023.09.013
UR  - https://inrepo02.dkfz.de/record/284937
ER  -