Home > Publications database > Large-Scale Meta-GWAS Reveals Common Genetic Factors Linked to Radiation-Induced Acute Toxicities across Cancers. > print

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005     20240229155058.0
024 7 _ |a 10.1093/jncics/pkad088
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024 7 _ |a pmid:37862240
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037 _ _ |a DKFZ-2023-02138
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Naderi, Elnaz
|b 0
245 _ _ |a Large-Scale Meta-GWAS Reveals Common Genetic Factors Linked to Radiation-Induced Acute Toxicities across Cancers.
260 _ _ |a Oxford
|c 2023
|b Oxford University Press
336 7 _ |a article
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336 7 _ |a ARTICLE
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500 _ _ |a 2023 Oct 31;7(6):pkad088
520 _ _ |a This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity (RIT) across four cancer types (prostate, head and neck, breast, and lung).A GWAS meta-analysis was performed using 19 cohorts including 12,042 patients. Acute standardized total average toxicity (rSTATacute) was modelled using a generalized linear regression model for additive effect of genetic variants adjusted for demographic and clinical covariates. LD score regression estimated shared SNP-based heritability of rSTATacute in all patients and for each cancer type.Shared SNP-based heritability of STATacute among all cancer types was estimated at 10% (se = 0.02), and was higher for prostate (17%, se = 0.07), head and neck (27%, se = 0.09), and breast (16%, se = 0.09) cancers. We identified 130 suggestive associated SNPs with rSTATacute (5.0x10-8
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650 _ 7 |a GWAS
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650 _ 7 |a Radiogenomics
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650 _ 7 |a SNP-based heritability
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650 _ 7 |a acute radiation-induced toxicity
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700 1 _ |a Aguado-Barrera, Miguel E
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700 1 _ |a Schack, Line M H
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700 1 _ |a Dorling, Leila
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700 1 _ |a Rattay, Tim
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700 1 _ |a Fachal, Laura
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700 1 _ |a Summersgill, Holly
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700 1 _ |a Martínez-Calvo, Laura
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700 1 _ |a Welsh, Ceilidh
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700 1 _ |a Dudding, Tom
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700 1 _ |a Odding, Yasmin
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700 1 _ |a Varela-Pazos, Ana
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700 1 _ |a Jena, Rajesh
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700 1 _ |a Thomson, David J
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700 1 _ |a Steenbakkers, Roel J H M
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700 1 _ |a Dennis, Joe
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700 1 _ |a Lobato-Busto, Ramón
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700 1 _ |a Alsner, Jan
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700 1 _ |a Ness, Andy
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700 1 _ |a Nutting, Chris
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700 1 _ |a Gómez-Caamaño, Antonio
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700 1 _ |a Eriksen, Jesper G
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700 1 _ |a Thomas, Steve J
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700 1 _ |a Bates, Amy M
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700 1 _ |a Webb, Adam J
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700 1 _ |a Choudhury, Ananya
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700 1 _ |a Rosenstein, Barry S
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700 1 _ |a Taboada-Valladares, Begona
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700 1 _ |a Herskind, Carsten
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700 1 _ |a Azria, David
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700 1 _ |a Dearnaley, David P
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700 1 _ |a de Ruysscher, Dirk
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700 1 _ |a Sperk, Elena
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700 1 _ |a Hall, Emma
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700 1 _ |a De Ruyck, Kim
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700 1 _ |a Veldeman, Liv
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700 1 _ |a Altabas, Manuel
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700 1 _ |a De Santis, Maria Carmen
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700 1 _ |a Farcy-Jacquet, Marie-Pierre
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700 1 _ |a Sydes, Matthew R
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700 1 _ |a Parliament, Matthew
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700 1 _ |a Usmani, Nawaid
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700 1 _ |a Mollà, Meritxell
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700 1 _ |a Gulliford, Sarah L
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700 1 _ |a Rancati, Tiziana
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700 1 _ |a Lambrecht, Maarten
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700 1 _ |a Pring, Miranda
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700 1 _ |a Duprez, Fréderic
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700 1 _ |a Talbot, Christopher J
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700 1 _ |a Barnett, Gillian C
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700 1 _ |a Dunning, Alison M
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700 1 _ |a Vega, Ana
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700 1 _ |a Andreassen, Christian Nicolaj
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700 1 _ |a Langendijk, Johannes A
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700 1 _ |a West, Catharine M L
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700 1 _ |a Alizadeh, Behrooz Z
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700 1 _ |a Kerns, Sarah L
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700 1 _ |a Consortium, On the behalf of the Radiogenomics
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