%0 Journal Article
%A Arbuznikova, Daria
%A Eder, Matthias
%A Grosu, Anca-Ligia
%A Meyer, Philipp T
%A Gratzke, Christian
%A Zamboglou, Constantinos
%A Eder, Ann-Christin
%T Towards Improving the Efficacy of PSMA-Targeting Radionuclide Therapy for Late-Stage Prostate Cancer-Combination Strategies.
%J Current oncology reports
%V 25
%N 11
%@ 1523-3790
%C Philadelphia, Pa.
%I Current Science, Inc.
%M DKFZ-2023-02139
%P 1363-1374
%D 2023
%Z 2023 Nov;25(11):1363-1374
%X [177Lu]Lu-PSMA-617 is a radiopharmaceutical that emits beta-minus radiation and targets prostate-specific membrane antigen (PSMA)-positive prostate cancer. Despite its clinical success, there are still patients not showing sufficient response rates. This review compiles latest studies aiming at therapy improvement in [177Lu]Lu-PSMA-617-naïve and -resistant patients by alternative or combination treatments.A variety of agents to combine with [177Lu]Lu-PSMA-617 are currently under investigation including alpha radiation-emitting pharmaceuticals, radiosensitizers, taxane chemotherapeutics, androgen receptor pathway inhibitors, immune checkpoint inhibitors, and external beam radiation. Actinium-225 (225Ac)-labeled PSMA-targeting inhibitors are the most studied pharmaceuticals for combination therapy or as an alternative for treatment after progression under [177Lu]Lu-PSMA-617 therapy. Alpha emitters seem to have a potential of achieving a response to PSMA-targeting radionuclide therapy in both initial non-responders or responders to [177Lu]Lu-PSMA-617 later developing treatment resistance. Emerging evidence for immunostimulatory effects of radiopharmaceuticals and first prospective studies support the combination of [177Lu]Lu-PSMA-617 and immune checkpoint inhibition for late-stage prostate cancer.
%K Combination therapy (Other)
%K Lutetium-177-PSMA-617 (Other)
%K Metastatic castration-resistant prostate cancer (Other)
%K Prostate-specific membrane antigen (Other)
%K Radioligand therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37861915
%R 10.1007/s11912-023-01458-6
%U https://inrepo02.dkfz.de/record/284939