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@ARTICLE{Lange:284943,
      author       = {P. F. Lange and O. Schilling$^*$ and P. F. Huesgen},
      title        = {{P}ositional proteomics: is the technology ready to study
                      clinical cohorts?},
      journal      = {Expert review of proteomics},
      volume       = {20},
      number       = {12},
      issn         = {1478-9450},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2023-02143},
      pages        = {309-318},
      year         = {2023},
      note         = {2023 Jul-Dec;20(12):309-318},
      abstract     = {Positional proteomics provides proteome-wide information on
                      protein termini and their modifications, uniquely enabling
                      unambiguous identification of site-specific, limited
                      proteolysis. Such proteolytic cleavage irreversibly modifies
                      protein sequences resulting in new proteoforms with distinct
                      protease-generated neo-N and C-termini and altered
                      localization, activity. Mis regulated proteolysis is
                      implicated in a wide variety of human diseases. Protein
                      termini, therefore, constitute a huge, largely unexplored
                      source of specific analytes that provides a deep view into
                      the functional proteome and a treasure trove for
                      biomarkers.We briefly review principal approaches to define
                      protein termini and discuss recent advances in method
                      development. We further highlight the potential of
                      positional proteomics to identify and trace specific
                      proteoforms, with a focus on proteolytic processes altered
                      in disease. Lastly, we discuss current challenges and
                      potential for applying positional proteomics in biomarker
                      and pre-clinical research.Recent developments in positional
                      proteomics have provided significant advances in sensitivity
                      and throughput. In-depth analysis of proteolytic processes
                      in clinical cohorts thus appears feasible in the near
                      future. We argue that this will provide insights into the
                      functional state of the proteome and offer new opportunities
                      to utilize proteolytic processes altered or targeted in
                      disease as specific diagnostic, prognostic and companion
                      biomarkers.},
      keywords     = {HUNTER (Other) / Positional proteomics (Other) / biomarker
                      (Other) / degradomics (Other) / proteoform (Other) /
                      proteolysis (Other) / terminomics (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37869791},
      doi          = {10.1080/14789450.2023.2272046},
      url          = {https://inrepo02.dkfz.de/record/284943},
}