TY  - JOUR
AU  - Wilferth, Tobias
AU  - Mennecke, Angelika
AU  - Huhn, Konstantin
AU  - Uder, Michael
AU  - Doerfler, Arnd
AU  - Schmidt, Manuel
AU  - Nagel, Armin
TI  - Influence of Residual Quadrupolar Interaction on Quantitative Sodium Brain Magnetic Resonance Imaging of Patients With Multiple Sclerosis.
JO  - Investigative radiology
VL  - 58
IS  - 10
SN  - 0020-9996
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Ovid
M1  - DKFZ-2023-02148
SP  - 730 - 739
PY  - 2023
N1  - #LA:E020#
AB  - The purpose of this work was to evaluate the influence of residual quadrupolar interaction on the determination of human brain apparent tissue sodium concentrations (aTSCs) using quantitative sodium magnetic resonance imaging ( 23 Na MRI) in healthy controls (HCs) and patients with multiple sclerosis (MS). Especially, it was investigated if the more detailed examination of residual quadrupolar interaction effects enables further analysis of the observed 23 Na MRI signal increase in MS patients.23 Na MRI with a 7 T MR system was performed on 21 HC and 50 MS patients covering all MS subtypes (25 patients with relapsing-remitting MS, 14 patients with secondary progressive MS, and 11 patients with primary progressive MS) using 2 different 23 Na pulse sequences for quantification: a commonly used standard sequence (aTSC Std ) as well as a sequence with shorter excitation pulse length and lower flip angle for minimizing signal loss resulting from residual quadrupolar interactions (aTSC SP ). Apparent tissue sodium concentration was determined using the same postprocessing pipeline including correction of the receive profile of the radiofrequency coil, partial volume correction, and relaxation correction. Spin dynamic simulations of spin-3/2 nuclei were performed to aid in the understanding of the measurement results and to get deeper insight in the underlying mechanisms.In normal-appearing white matter (NAWM) of HC and all MS subtypes, the aTSC SP values were approximately 20
KW  - Humans
KW  - Multiple Sclerosis: diagnostic imaging
KW  - Multiple Sclerosis: pathology
KW  - Sodium
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Magnetic Resonance Imaging: methods
KW  - Multiple Sclerosis, Relapsing-Remitting: diagnostic imaging
KW  - Multiple Sclerosis, Relapsing-Remitting: pathology
KW  - Sexually Transmitted Diseases: pathology
KW  - Sodium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37185832
DO  - DOI:10.1097/RLI.0000000000000981
UR  - https://inrepo02.dkfz.de/record/284950
ER  -