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| 001 | 284950 | ||
| 005 | 20240229155058.0 | ||
| 024 | 7 | _ | |a 10.1097/RLI.0000000000000981 |2 doi |
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| 024 | 7 | _ | |a 0020-9996 |2 ISSN |
| 024 | 7 | _ | |a 1536-0210 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2023-02148 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Wilferth, Tobias |b 0 |
| 245 | _ | _ | |a Influence of Residual Quadrupolar Interaction on Quantitative Sodium Brain Magnetic Resonance Imaging of Patients With Multiple Sclerosis. |
| 260 | _ | _ | |a [Erscheinungsort nicht ermittelbar] |c 2023 |b Ovid |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1698413735_6651 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:E020# |
| 520 | _ | _ | |a The purpose of this work was to evaluate the influence of residual quadrupolar interaction on the determination of human brain apparent tissue sodium concentrations (aTSCs) using quantitative sodium magnetic resonance imaging ( 23 Na MRI) in healthy controls (HCs) and patients with multiple sclerosis (MS). Especially, it was investigated if the more detailed examination of residual quadrupolar interaction effects enables further analysis of the observed 23 Na MRI signal increase in MS patients.23 Na MRI with a 7 T MR system was performed on 21 HC and 50 MS patients covering all MS subtypes (25 patients with relapsing-remitting MS, 14 patients with secondary progressive MS, and 11 patients with primary progressive MS) using 2 different 23 Na pulse sequences for quantification: a commonly used standard sequence (aTSC Std ) as well as a sequence with shorter excitation pulse length and lower flip angle for minimizing signal loss resulting from residual quadrupolar interactions (aTSC SP ). Apparent tissue sodium concentration was determined using the same postprocessing pipeline including correction of the receive profile of the radiofrequency coil, partial volume correction, and relaxation correction. Spin dynamic simulations of spin-3/2 nuclei were performed to aid in the understanding of the measurement results and to get deeper insight in the underlying mechanisms.In normal-appearing white matter (NAWM) of HC and all MS subtypes, the aTSC SP values were approximately 20% higher than the aTSC Std values ( P < 0.001). In addition, the ratio aTSC SP /aTSC Std was significantly higher in NAWM than in normal-appearing gray matter (NAGM) for all subject cohorts ( P < 0.002). In NAWM, aTSC Std values were significantly higher in primary progressive MS compared with HC ( P = 0.01) as well as relapsing-remitting MS ( P = 0.03). However, in contrast, no significant differences between the subject cohorts were found for aTSC SP . Spin simulations assuming the occurrence of residual quadrupolar interaction in NAWM were in good accordance with the measurement results, in particular, the ratio aTSC SP /aTSC Std in NAWM and NAGM.Our results showed that residual quadrupolar interactions in white matter regions of the human brain have an influence on aTSC quantification and therefore must be considered, especially in pathologies with expected microstructural changes such as loss of myelin in MS. Furthermore, the more detailed examination of residual quadrupolar interactions may lead to a better understanding of the pathologies themselves. |
| 536 | _ | _ | |a 315 - Bildgebung und Radioonkologie (POF4-315) |0 G:(DE-HGF)POF4-315 |c POF4-315 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a Sodium |0 9NEZ333N27 |2 NLM Chemicals |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Multiple Sclerosis: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Multiple Sclerosis: pathology |2 MeSH |
| 650 | _ | 2 | |a Sodium |2 MeSH |
| 650 | _ | 2 | |a Brain: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Brain: pathology |2 MeSH |
| 650 | _ | 2 | |a Magnetic Resonance Imaging: methods |2 MeSH |
| 650 | _ | 2 | |a Multiple Sclerosis, Relapsing-Remitting: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Multiple Sclerosis, Relapsing-Remitting: pathology |2 MeSH |
| 650 | _ | 2 | |a Sexually Transmitted Diseases: pathology |2 MeSH |
| 700 | 1 | _ | |a Mennecke, Angelika |b 1 |
| 700 | 1 | _ | |a Huhn, Konstantin |b 2 |
| 700 | 1 | _ | |a Uder, Michael |b 3 |
| 700 | 1 | _ | |a Doerfler, Arnd |b 4 |
| 700 | 1 | _ | |a Schmidt, Manuel |b 5 |
| 700 | 1 | _ | |a Nagel, Armin |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1097/RLI.0000000000000981 |g Vol. 58, no. 10, p. 730 - 739 |0 PERI:(DE-600)2041543-6 |n 10 |p 730 - 739 |t Investigative radiology |v 58 |y 2023 |x 0020-9996 |
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