TY  - JOUR
AU  - Chen, Xuechen
AU  - Heisser, Thomas
AU  - Cardoso, Rafael
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Personalized Initial Screening Age for Colorectal Cancer in Individuals at Average Risk.
JO  - JAMA network open
VL  - 6
IS  - 10
SN  - 2574-3805
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2023-02171
SP  - e2339670
PY  - 2023
N1  - #EA:C070#LA:C070#LA:C120#
AB  - Colorectal cancer (CRC) risk varies widely in the population at average risk without a family history, but there are no established routines for translating this variation into personalized starting ages of screening.To illustrate derivation of risk-adapted starting ages of CRC screening based on the concept of risk advancement period (RAP) using sex and a polygenic risk score (PRS) as an example.This cohort study included participants in the UK Biobank study recruited in England, Wales, and Scotland between March 13, 2006, and October 1, 2010. Participants were aged 40 to 69 years, with no previous bowel cancer screening and no family history of CRC. Follow-up of cancer data was completed February 29, 2020, for England and Wales and January 31, 2021, for Scotland. The censoring date for death data was September 30, 2021, for England and Wales and October 31, 2021, for Scotland.Data on age, sex, and family history were collected at the baseline interview. A PRS was calculated based on 139 CRC-related risk loci.Hazard ratios (HRs) of sex and PRS with CRC risk and mortality were estimated using Cox proportional hazards regression models and were translated to RAPs to quantify how many years of age earlier or later men and individuals in higher or lower PRS deciles would reach risks comparable with those of the reference group (ie, women or those in the 5th and 6th PRS deciles).Among 242 779 participants (median age, 55 [IQR, 48-61] years; 55.7
KW  - Male
KW  - Humans
KW  - Female
KW  - Middle Aged
KW  - Early Detection of Cancer
KW  - Cohort Studies
KW  - Risk Factors
KW  - England
KW  - Multifactorial Inheritance
KW  - Neoplasms
LB  - PUB:(DE-HGF)16
C6  - pmid:37878311
DO  - DOI:10.1001/jamanetworkopen.2023.39670
UR  - https://inrepo02.dkfz.de/record/284987
ER  -