% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Chen:284987,
      author       = {X. Chen$^*$ and T. Heisser$^*$ and R. Cardoso$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{P}ersonalized {I}nitial {S}creening {A}ge for {C}olorectal
                      {C}ancer in {I}ndividuals at {A}verage {R}isk.},
      journal      = {JAMA network open},
      volume       = {6},
      number       = {10},
      issn         = {2574-3805},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {DKFZ-2023-02171},
      pages        = {e2339670},
      year         = {2023},
      note         = {#EA:C070#LA:C070#LA:C120#},
      abstract     = {Colorectal cancer (CRC) risk varies widely in the
                      population at average risk without a family history, but
                      there are no established routines for translating this
                      variation into personalized starting ages of screening.To
                      illustrate derivation of risk-adapted starting ages of CRC
                      screening based on the concept of risk advancement period
                      (RAP) using sex and a polygenic risk score (PRS) as an
                      example.This cohort study included participants in the UK
                      Biobank study recruited in England, Wales, and Scotland
                      between March 13, 2006, and October 1, 2010. Participants
                      were aged 40 to 69 years, with no previous bowel cancer
                      screening and no family history of CRC. Follow-up of cancer
                      data was completed February 29, 2020, for England and Wales
                      and January 31, 2021, for Scotland. The censoring date for
                      death data was September 30, 2021, for England and Wales and
                      October 31, 2021, for Scotland.Data on age, sex, and family
                      history were collected at the baseline interview. A PRS was
                      calculated based on 139 CRC-related risk loci.Hazard ratios
                      (HRs) of sex and PRS with CRC risk and mortality were
                      estimated using Cox proportional hazards regression models
                      and were translated to RAPs to quantify how many years of
                      age earlier or later men and individuals in higher or lower
                      PRS deciles would reach risks comparable with those of the
                      reference group (ie, women or those in the 5th and 6th PRS
                      deciles).Among 242 779 participants (median age, 55 [IQR,
                      48-61] years; $55.7\%$ women), 2714 incident CRC cases were
                      identified during a median follow-up of 11.2 (IQR,
                      10.5-11.8) years and 758 deaths during a median follow-up of
                      12.8 (IQR, 12.0-13.4) years. The HRs of CRC risk were 1.57
                      $(95\%$ CI, 1.46-1.70) for men vs women and ranged from 0.51
                      $(95\%$ CI, 0.41-0.62) to 2.29 $(95\%$ CI, 2.01-2.62) across
                      PRS deciles compared with the reference. The RAPs were 5.6
                      $(95\%$ CI, 4.6-6.6) years for men vs women and ranged from
                      -8.4 $(95\%$ CI, -11.0 to -5.9) to 10.3 $(95\%$ CI,
                      8.5-12.1) years across PRS deciles compared with the
                      reference deciles. Risk-adapted starting ages of screening
                      would vary by 24 years between men in the highest PRS decile
                      and women in the lowest PRS decile. Similar results were
                      obtained regarding CRC mortality.In this large cohort study
                      including women and men at average risk of CRC, risk-adapted
                      starting ages of screening strongly varied by sex and a PRS.
                      The RAP concept could easily accommodate additional factors
                      for defining personalized starting ages of screening.},
      keywords     = {Male / Humans / Female / Middle Aged / Early Detection of
                      Cancer / Cohort Studies / Risk Factors / England /
                      Multifactorial Inheritance / Neoplasms},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37878311},
      doi          = {10.1001/jamanetworkopen.2023.39670},
      url          = {https://inrepo02.dkfz.de/record/284987},
}