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@ARTICLE{BlancoCarmona:285005,
      author       = {E. Blanco-Carmona$^*$ and A. Narayanan and I. Hernandez and
                      J. C. Nieto and M. Elosua-Bayes and X. Sun$^*$ and C.
                      Schmidt$^*$ and N. Pamir and K. Özduman and C. Herold-Mende
                      and F. Pagani and M. Cominelli and J. Taranda$^*$ and W.
                      Wick$^*$ and A. von Deimling$^*$ and P. L. Poliani and M.
                      Rehli and M. Schlesner and H. Heyn and S. Turcan$^*$},
      title        = {{T}umor heterogeneity and tumor-microglia interactions in
                      primary and recurrent {IDH}1-mutant gliomas.},
      journal      = {Cell reports / Medicine},
      volume       = {4},
      number       = {11},
      issn         = {2666-3791},
      address      = {Maryland Heights, MO},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-02178},
      pages        = {101249},
      year         = {2023},
      note         = {#EA:B062#LA:B320# / 2023 Nov 21;4(11):101249},
      abstract     = {The isocitrate dehydrogenase (IDH) gene is recurrently
                      mutated in adult diffuse gliomas. IDH-mutant gliomas are
                      categorized into oligodendrogliomas and astrocytomas, each
                      with unique pathological features. Here, we use
                      single-nucleus RNA and ATAC sequencing to compare the
                      molecular heterogeneity of these glioma subtypes. In
                      addition to astrocyte-like, oligodendrocyte progenitor-like,
                      and cycling tumor subpopulations, a tumor population
                      enriched for ribosomal genes and translation elongation
                      factors is primarily present in oligodendrogliomas.
                      Longitudinal analysis of astrocytomas indicates that the
                      proportion of tumor subpopulations remains stable in
                      recurrent tumors. Analysis of tumor-associated
                      microglia/macrophages (TAMs) reveals significant differences
                      between oligodendrogliomas, with astrocytomas harboring
                      inflammatory TAMs expressing phosphorylated STAT1, as
                      confirmed by immunohistochemistry. Furthermore, inferred
                      receptor-ligand interactions between tumor subpopulations
                      and TAMs may contribute to TAM state diversity. Overall, our
                      study sheds light on distinct tumor populations, TAM
                      heterogeneity, TAM-tumor interactions in IDH-mutant glioma
                      subtypes, and the relative stability of tumor subpopulations
                      in recurrent astrocytomas.},
      keywords     = {IDH mutation (Other) / astrocytoma (Other) /
                      bone-marrow-derived macrophages (Other) / glioma (Other) /
                      microglia (Other) / oligodendroglioma (Other) / recurrent
                      glioma (Other) / snATAC-seq (Other) / snRNA-seq (Other) /
                      tumor microenvironment (Other)},
      cin          = {B062 / HD01 / W210 / B320 / B300},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)W210-20160331 / I:(DE-He78)B320-20160331 /
                      I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37883975},
      doi          = {10.1016/j.xcrm.2023.101249},
      url          = {https://inrepo02.dkfz.de/record/285005},
}