TY  - JOUR
AU  - Laschinsky, Christina
AU  - Theurer, Sarah
AU  - Herold, Thomas
AU  - Rawitzer, Josefine
AU  - Weber, Frank
AU  - Herrmann, Ken
AU  - Brandenburg, Tim
AU  - Führer-Sakel, Dagmar
AU  - Fendler, Wolfgang P
AU  - Weber, Manuel
TI  - Molecular Markers Are Associated with Onset of Radioiodine Refractoriness in Patients with Papillary Thyroid Carcinoma.
JO  - Journal of nuclear medicine
VL  - 64
IS  - 12
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2023-02182
SP  - 1865-1868
PY  - 2023
N1  - 2023 Dec 1;64(12):1865-1868
AB  - The onset of radioiodine-refractory thyroid carcinoma (RR-TC) is a negative predictor of survival and has been linked to the presence of BRAFV600E mutations in papillary thyroid cancer. We aimed to identify further genetic alterations associated with RR-TC. Methods: We included 38 patients with papillary thyroid cancer who underwent radioiodine imaging and 18F-FDG PET/CT after total thyroidectomy. The molecular profile was assessed by next-generation sequencing. The time to the onset of RR-TC for different genetic alterations was compared using the log-rank test. Results: The median onset to RR-TC was 0.7 and 19.8 mo in patients with and without, respectively, telomerase reverse transcriptase promoter mutations (P = 0.02) and 1.7 and 19.8 mo in patients with and without, respectively, a tumor protein 53 mutation (P < 0.01). This association was not observed for BRAFV600E mutations (P = 0.49). Conclusion: Our data show a significant association between the onset of RR-TC and mutations in telomerase reverse transcriptase promoter and tumor protein 53, indicating the need for a more extensive diagnostic workup in these patients. Certain genetic changes put patients with thyroid cancer at risk of developing cancer spread that does not respond to radioiodine therapy.
KW  - TP53 (Other)
KW  - molecular alterations (Other)
KW  - molecular imaging (Other)
KW  - papillary thyroid cancer (Other)
KW  - radioiodine refractoriness (Other)
KW  - radionuclide therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37884333
DO  - DOI:10.2967/jnumed.123.266044
UR  - https://inrepo02.dkfz.de/record/285009
ER  -