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@ARTICLE{Vogel:285045,
      author       = {J. Vogel and F. Seith and A. Estler and K. Nikolaou$^*$ and
                      H. Schmidt and C. la Fougère$^*$ and T. Küstner},
      title        = {{I}mpact of {T}racer {D}ose {R}eduction in [18
                      {F}]-{L}abelled {F}luorodeoxyglucose-{P}ositron {E}mission
                      {T}omography ([18 {F}]-{FDG})-{PET}) on {T}exture {F}eatures
                      and {H}istogram {I}ndices: {A} {S}tudy in {H}omogeneous
                      {T}issues of {P}hantom and {P}atient.},
      journal      = {Tomography},
      volume       = {9},
      number       = {5},
      issn         = {2379-1381},
      address      = {Ann Arbor, Michigan},
      publisher    = {Grapho Publications},
      reportid     = {DKFZ-2023-02188},
      pages        = {1799 - 1810},
      year         = {2023},
      abstract     = {Histogram indices (HIs) and texture features (TFs) are
                      considered to play an important role in future oncologic
                      PET-imaging and it is unknown how these indices are affected
                      by changes of tracer doses. A randomized undersampling of
                      PET list mode data enables a simulation of tracer dose
                      reduction. We performed a phantom study to compare HIs/TFs
                      of simulated and measured tracer dose reductions and
                      evaluated changes of HIs/TFs in the liver of patients with
                      PETs from simulated reduced tracer doses. Overall, 42
                      HIs/TFs were evaluated in a NEMA phantom at measured and
                      simulated doses (stepwise reduction of [18 F] from $100\%$
                      to $25\%$ of the measured dose). [18 F]-FDG-PET datasets of
                      15 patients were simulated from 3.0 down to 0.5 MBq/kgBW in
                      intervals of 0.25 MBq/kgBW. HIs/TFs were calculated from two
                      VOIs placed in physiological tissue of the right and left
                      liver lobe and linear correlations and coefficients of
                      variation analysis were performed.All 42 TFs did not differ
                      significantly in measured and simulated doses (p > 0.05).
                      Also, 40 TFs showed the same behaviour over dose reduction
                      regarding differences in the same group (measured or
                      simulated), and for 26 TFs a linear behaviour over dose
                      reduction for measured and simulated doses could be
                      validated. Out of these, 13 TFs could be identified, which
                      showed a linear change in TF value in both the NEMA phantom
                      and patient data and therefore should maintain the same
                      informative value when transferred in a dose reduction
                      setting. Out of this Homogeneity 2, Entropy and Zone size
                      non-uniformity are of special interest because they have
                      been described as preferentially considerable for tumour
                      heterogeneity characterization.We could show that there was
                      no significant difference of measured and simulated HIs/TFs
                      in the phantom study and most TFs reveal a linear behaviour
                      over dose reduction, when tested in homogeneous tissue. This
                      indicates that texture analysis in PET might be robust to
                      dose modulations.},
      keywords     = {Humans / Fluorodeoxyglucose F18 / Drug Tapering /
                      Positron-Emission Tomography: methods / Radiopharmaceuticals
                      / Neoplasms: diagnostic imaging / Neoplasms: radiotherapy /
                      FDG (Other) / PET (Other) / dose reduction (Other) /
                      radiomics (Other) / texture features (Other) /
                      Fluorodeoxyglucose F18 (NLM Chemicals) /
                      Radiopharmaceuticals (NLM Chemicals)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37888735},
      pmc          = {pmc:PMC10611106},
      doi          = {10.3390/tomography9050143},
      url          = {https://inrepo02.dkfz.de/record/285045},
}