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@ARTICLE{Wandrey:285050,
      author       = {M. Wandrey and J. Jablonska$^*$ and R. H. Stauber and D.
                      Gül},
      title        = {{E}xosomes in {C}ancer {P}rogression and {T}herapy
                      {R}esistance: {M}olecular {I}nsights and {T}herapeutic
                      {O}pportunities.},
      journal      = {Life},
      volume       = {13},
      number       = {10},
      issn         = {2075-1729},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-02193},
      pages        = {2033},
      year         = {2023},
      abstract     = {The development of therapy resistance still represents a
                      major hurdle in treating cancers, leading to impaired
                      treatment success and increased patient morbidity. The
                      establishment of minimally invasive liquid biopsies is a
                      promising approach to improving the early diagnosis, as well
                      as therapy monitoring, of solid tumors. Because of their
                      manifold functions in the tumor microenvironment,
                      tumor-associated small extracellular vesicles, referred to
                      as exosomes, have become a subject of intense research.
                      Besides their important roles in cancer progression,
                      metastasis, and the immune response, it has been proposed
                      that exosomes also contribute to the acquisition and
                      transfer of therapy resistance, mainly by delivering
                      functional proteins and RNAs, as well as facilitating the
                      export of active drugs or functioning as extracellular
                      decoys. Extensive research has focused on understanding the
                      molecular mechanisms underlying the occurrence of resistance
                      and translating these into strategies for early detection.
                      With this review, we want to provide an overview of the
                      current knowledge about the (patho-)biology of exosomes, as
                      well as state-of-the-art methods of isolation and analysis.
                      Furthermore, we highlight the role of exosomes in
                      tumorigenesis and cancer treatment, where they can function
                      as therapeutic agents, biomarkers, and/or targets. By
                      focusing on their roles in therapy resistance, we will
                      reveal new paths of exploiting exosomes for cancer diagnosis
                      and treatment.},
      subtyp        = {Review Article},
      keywords     = {cancer (Other) / cancer therapy (Other) / exosomes (Other)
                      / resistance transmission (Other) / therapy resistance
                      (Other)},
      cin          = {ED01},
      ddc          = {570},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37895415},
      pmc          = {pmc:PMC10608050},
      doi          = {10.3390/life13102033},
      url          = {https://inrepo02.dkfz.de/record/285050},
}