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@ARTICLE{Caldern:285054,
      author       = {E. Calderón and F. P. Schmidt and W. Lan and S.
                      Castaneda-Vega and A. S. Brendlin and N. F. Trautwein and H.
                      Dittmann and C. la Fougère$^*$ and L. S. Kiefer},
      title        = {{I}mage {Q}uality and {Q}uantitative {PET} {P}arameters of
                      {L}ow-{D}ose [18{F}]{FDG} {PET} in a {L}ong {A}xial
                      {F}ield-of-{V}iew {PET}/{CT} {S}canner.},
      journal      = {Diagnostics},
      volume       = {13},
      number       = {20},
      issn         = {2075-4418},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-02197},
      pages        = {3240},
      year         = {2023},
      abstract     = {PET/CT scanners with a long axial field-of-view (LAFOV)
                      provide increased sensitivity, enabling the adjustment of
                      imaging parameters by reducing the injected activity or
                      shortening the acquisition time. This study aimed to
                      evaluate the limitations of reduced [18F]FDG activity doses
                      on image quality, lesion detectability, and the
                      quantification of lesion uptake in the Biograph Vision
                      Quadra, as well as to assess the benefits of the recently
                      introduced ultra-high sensitivity mode in a clinical
                      setting. A number of 26 patients who underwent
                      [18F]FDG-PET/CT (3.0 MBq/kg, 5 min scan time) were included
                      in this analysis. The PET raw data was rebinned for shorter
                      frame durations to simulate 5 min scans with lower
                      activities in the high sensitivity (HS) and ultra-high
                      sensitivity (UHS) modes. Image quality, noise, and lesion
                      detectability (n = 82) were assessed using a 5-point Likert
                      scale. The coefficient of variation (CoV), signal-to-noise
                      ratio (SNR), tumor-to-background ratio (TBR), and
                      standardized uptake values (SUV) including SUVmean, SUVmax,
                      and SUVpeak were evaluated. Subjective image ratings were
                      generally superior in UHS compared to the HS mode. At 0.5
                      MBq/kg, lesion detectability decreased to $95\%$ (HS) and to
                      $98\%$ (UHS). SNR was comparable at 1.0 MBq/kg in HS (5.7 ±
                      0.6) and 0.5 MBq/kg in UHS (5.5 ± 0.5). With lower doses,
                      there were negligible reductions in SUVmean and SUVpeak,
                      whereas SUVmax increased steadily. Reducing the [18F]FDG
                      activity to 1.0 MBq/kg (HS/UHS) in a LAFOV PET/CT provides
                      diagnostic image quality without statistically significant
                      changes in the uptake parameters. The UHS mode improves
                      image quality, noise, and lesion detectability compared to
                      the HS mode.},
      keywords     = {LAFOV PET/CT (Other) / [18F]FDG (Other) / low-dose [18F]FDG
                      PET (Other) / total-body PET/CT scanner (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37892061},
      pmc          = {pmc:PMC10606613},
      doi          = {10.3390/diagnostics13203240},
      url          = {https://inrepo02.dkfz.de/record/285054},
}