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@ARTICLE{Burth:285116,
      author       = {S. Burth and J. Meis and D. Kronsteiner and H. Heckhausen
                      and K. Zweckberger and M. Kieser and W. Wick$^*$ and C.
                      Ulfert and M. Möhlenbruch and P. Ringleb and S.
                      Schönenberger},
      title        = {{O}utcome analysis for patients with subarachnoid
                      hemorrhage and vasospasm including endovascular treatment.},
      journal      = {Neurological research and practice},
      volume       = {5},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2023-02240},
      pages        = {57},
      year         = {2023},
      abstract     = {As a complication of subarachnoid hemorrhage (SAH),
                      vasospasm substantially contributes to its morbidity and
                      mortality. We aimed at analyzing predictors of outcome for
                      these patients including the role of endovascular treatment
                      (ET). Our database was screened for patients with SAH
                      treated in our Neuro-ICU from 2009 to 2019. Clinical
                      parameters including functional outcome (modified Rankin
                      Scale, mRS of 0-2 or 3-6 at discharge and after a median
                      follow-up of 18 months) and details about ET were gathered
                      on 465 patients, 241 $(52\%)$ of whom experienced vasospasm.
                      Descriptive analyses were performed to identify explanatory
                      variables for the dichotomized mRS score. A logistic
                      regression model was fitted on 241 patients with vasospasm
                      including age, Hunt and Hess Score, extraventricular
                      drainage (EVD), forced hypertension, ET and delayed cerebral
                      ischemia (DCI). The model found a Hunt and Hess Score of 5
                      (OR = 0.043, p = 0.008), requirement of EVD (OR = 0.161, p <
                      0.001), forced hypertension (OR = 0.242, p = 0.001), ET (OR
                      = 0.431, p = 0.043) and DCI (OR = 0.229, p < 0.001) to be
                      negative predictors of outcome while age was not. Use of
                      intraarterial nimodipine alone (OR = 0.778, p = 0.705) or
                      including balloon angioplasty (OR = 0.894, p = 0.902) and
                      number of ETs per patient (OR = 0.757, p = 0.416) were not
                      significant in a separate model with otherwise identical
                      variables. While DCI is clearly associated with poor
                      outcome, the influence of ET on outcome remains
                      inconclusive. Limited by their retrospective nature and an
                      indication bias, these data encourage a randomized
                      assessment of ET.},
      keywords     = {Delayed cerebral ischemia (Other) / Endovascular treatment
                      (Other) / Outcome (Other) / Subarachnoid hemorrhage (Other)
                      / Vasospasm (Other)},
      cin          = {B320 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37915071},
      doi          = {10.1186/s42466-023-00283-3},
      url          = {https://inrepo02.dkfz.de/record/285116},
}