%0 Journal Article
%A Rühle, Alexander
%A Weymann, Maria
%A Behrens, Max
%A Marschner, Sebastian
%A Haderlein, Marlen
%A Fabian, Alexander
%A Senger, Carolin
%A Dickstein, Daniel R
%A Kraft, Johannes
%A der Grün, Jens von
%A Chen, Eric
%A Aquino-Michaels, Todd
%A Domschikowski, Justus
%A Bickel, Amanda
%A Altay-Langguth, Alev
%A Kalinauskaite, Goda
%A Lewitzki, Victor
%A Bonomi, Marcelo
%A Blakaj, Dukagjin M
%A Jhawar, Sachin R
%A Baliga, Sujith
%A Barve, Rahul
%A Ferentinos, Konstantinos
%A Zamboglou, Constantinos
%A Schnellhardt, Sören
%A Haehl, Erik
%A Spohn, Simon K B
%A Kuhnt, Thomas
%A Zöller, Daniela
%A Guckenberger, Matthias
%A Budach, Volker
%A Belka, Claus
%A Bakst, Richard
%A Mayer, Arnulf
%A Schmidberger, Heinz
%A Grosu, Anca-Ligia
%A Balermpas, Panagiotis
%A Stromberger, Carmen
%A Nicolay, Nils
%T A Multicenter Evaluation of Different Chemotherapy Regimens in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiation.
%J International journal of radiation oncology, biology, physics
%V 118
%N 5
%@ 0360-3016
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2023-02242
%P 1282-1293
%D 2024
%Z 2024 Apr 1;118(5):1282-1293 / #LA:E055#
%X The number of older adults with head-and-neck squamous cell carcinoma (HNSCC) is increasing, and treatment of these patients is challenging. Although cisplatin-based chemotherapy concomitantly with radiotherapy is considered standard regimen for patients with locoregionally advanced HNSCC, there is substantial real-world heterogeneity regarding concomitant chemotherapy in older HNSCC patients.The XXX study is an international multicenter cohort study including older (≥65 years) HNSCC patients treated with definitive radiotherapy at 13 academic centers in the United States and Europe. Here, patients with concomitant chemoradiation were analyzed regarding overall survival (OS) and progression-free survival (PFS) using Kaplan-Meier analyses, while Fine-Gray competing risks regressions were performed regarding the incidence of locoregional failures (LRFs) and distant metastases (DMs).Six hundred ninety-seven patients with a median age of 71 years were included in this analysis. Single-agent cisplatin was the most common chemotherapy regimen (n=310; 44
%K Radiotherapy (Other)
%K carboplatin (Other)
%K chemotherapy (Other)
%K cisplatin (Other)
%K elderly (Other)
%K geriatric (Other)
%K head and neck cancer (Other)
%K mitomycin (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37914144
%R 10.1016/j.ijrobp.2023.10.025
%U https://inrepo02.dkfz.de/record/285118